BDBM50048956 (R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propane-1-thiol::2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propane-1-thiol 6(FTI-263)::CHEMBL292164

SMILES Cc1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1

InChI Key InChIKey=NLKGJZMAJPDFMS-OAHLLOKOSA-N

Data  4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50048956   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50048956((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...)
Show SMILES Cc1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1
Show InChI InChI=1S/C16H20N2S/c1-12-3-2-4-14(9-12)13-5-7-16(8-6-13)18-10-15(17)11-19/h2-9,15,18-19H,10-11,17H2,1H3/t15-/m1/s1
Affinity DataIC50: 770nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50048956((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...)
Show SMILES Cc1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1
Show InChI InChI=1S/C16H20N2S/c1-12-3-2-4-14(9-12)13-5-7-16(8-6-13)18-10-15(17)11-19/h2-9,15,18-19H,10-11,17H2,1H3/t15-/m1/s1
Affinity DataIC50: 710nMAssay Description:In vitro inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
LigandPNGBDBM50048956((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...)
Show SMILES Cc1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1
Show InChI InChI=1S/C16H20N2S/c1-12-3-2-4-14(9-12)13-5-7-16(8-6-13)18-10-15(17)11-19/h2-9,15,18-19H,10-11,17H2,1H3/t15-/m1/s1
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
LigandPNGBDBM50048956((R)-2-Amino-3-(3'-methyl-biphenyl-4-ylamino)-propa...)
Show SMILES Cc1cccc(c1)-c1ccc(NC[C@@H](N)CS)cc1
Show InChI InChI=1S/C16H20N2S/c1-12-3-2-4-14(9-12)13-5-7-16(8-6-13)18-10-15(17)11-19/h2-9,15,18-19H,10-11,17H2,1H3/t15-/m1/s1
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair