BDBM50089084 CHEMBL3317857::Vaborbactam

SMILES OB1O[C@H](CC(O)=O)CC[C@@H]1NC(=O)Cc1cccs1

InChI Key InChIKey=IOOWNWLVCOUUEX-WPRPVWTQSA-N

Data  3 KI  9 IC50

PDB links: 10 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50089084   

TargetCarbapenem-hydrolyzing beta-lactamase KPC()
Qpex Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataKi:  56nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Qpex Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Qpex Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of urokinase (unknown origin) using NGK-pNA as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of tissue plasminogen activator (unknown origin) using GK-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of dipeptidyl peptidase 7 (unknown origin) using H-Lys-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of neutrophil elastase (unknown origin) using MeOSuc-AAVP-AMC as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal protective protein(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of cathepsin A (unknown origin) using MCA-RPPGFSAFK-Dnp as substrate preincubated for 10 mins followed by substrate addition measured for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of thrombin (unknown origin) using Benz-FVR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of plasmin (unknown origin) using H-D-VLK-pNA as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of trypsin (unknown origin) using N-Bz-R-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Rempex Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of chymase (unknown origin) using Suc-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed