BDBM50158336 2-(4-octylphenethyl)-2-aminopropane-1,3-diol::2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol::2-amino-2-(4-octylphenethyl)propane-1,3-diol::2-amino-2-(4-octylphenyl)ethylpropane-1,3-diol::CHEMBL314854::FINGOLIMOD::FINGOLIMOD HYDROCHLORIDE
SMILES CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
InChI Key InChIKey=KKGQTZUTZRNORY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50158336
Affinity DataKi: 2.15E+3nMAssay Description:Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 840nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin ...More data for this Ligand-Target Pair
Affinity DataEC50: 7.20nMAssay Description:Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+3nMAssay Description:Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...More data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.51E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.16E+3nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at S1P5 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at S1P3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at S1P4 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at S1P1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Mouse)
Spanish National Research Council (Csic)
Curated by ChEMBL
Spanish National Research Council (Csic)
Curated by ChEMBL
Affinity DataIC50: 5.24E+4nMAssay Description:Inhibition of mouse liver microsomal S1PL using S1P as substrate incubated for 20 mins by ESI-LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 604nMAssay Description:Inhibition of S1PR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Negative log concentration of antagonist on 5-hydroxytryptamine 2A receptor in rat thoracic aortaMore data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of S1PL (unknown origin)More data for this Ligand-Target Pair
TargetSphingosine-1-phosphate lyase 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair