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BDBM50240671 (5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydro-1H-imidazol-2-yl)-amine::CHEMBL1079::TIZANIDINE::Zanaflex

SMILES: Clc1ccc2nsnc2c1NC1=NCCN1

InChI Key: InChIKey=XFYDIVBRZNQMJC-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50240671   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Imidazoline receptor 1 (I1R)


(Homo sapiens (Human))
BDBM50240671
PNG
((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
PDB

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CHEMBL
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KEGG
PC cid
PC sid
UniChem

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Article
PubMed
28n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2AR


Bioorg Med Chem 16: 7134-40 (2008)


Article DOI: 10.1016/j.bmc.2008.06.051
BindingDB Entry DOI: 10.7270/Q2FX7BCP
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50240671
PNG
((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
UniProtKB/SwissProt

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CHEMBL
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KEGG
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PC sid
UniChem

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PubMed
62n/an/an/an/an/an/an/an/a



University of Nebraska

Curated by PDSP Ki Database




J Pharmacol Exp Ther 259: 323-9 (1991)


BindingDB Entry DOI: 10.7270/Q2Z899WV
More data for this
Ligand-Target Pair
ADRA2C


(OK)
BDBM50240671
PNG
((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
GoogleScholar
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CHEMBL
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KEGG
PC cid
PC sid
UniChem

Patents

PubMed
75n/an/an/an/an/an/an/an/a



University of Nebraska

Curated by PDSP Ki Database




J Pharmacol Exp Ther 259: 323-9 (1991)


BindingDB Entry DOI: 10.7270/Q2Z899WV
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(NEONATAL RAT)
BDBM50240671
PNG
((5-Chloro-benzo[1,2,5]thiadiazol-4-yl)-(4,5-dihydr...)
Show SMILES Clc1ccc2nsnc2c1NC1=NCCN1
Show InChI InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents

PubMed
76n/an/an/an/an/an/an/an/a



University of Nebraska

Curated by PDSP Ki Database




J Pharmacol Exp Ther 259: 323-9 (1991)


BindingDB Entry DOI: 10.7270/Q2Z899WV
More data for this
Ligand-Target Pair