BDBM50260797 3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL525361

SMILES Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=UXOKGMBZBAXMDM-UHFFFAOYSA-N

Data  10 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50260797   

LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 by SPA-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta-HSD1 by SPA-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse 11beta HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50260797(3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 11beta HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed