BDBM50298801 (+/-)-5-(3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::Biphenyl antifolate, 2::CHEMBL575217::US8853228, 140

SMILES: Cc1cc(cc(c1)c2cc(cc(c2)OC)[C@@H](C)C#Cc3c(nc(nc3N)N)C)C

InChI Key: InChIKey=ATFDKOLABYIYCC-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50298801   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Yeast)	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Human)	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Staphylococcus aureus)	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
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Dihydrofolate reductase (Streptococcus pyogenes (Firmicutes))	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Yeast)	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Staphylococcus aureus)	BDBM50298801 (Biphenyl antifolate, 2 | CHEMBL575217 | US8853228,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair