BDBM50306427 2-{1'-[(adamantan-2-yl)carbamoyl]-6-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL602051

SMILES OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2cc(Cl)ccc12

InChI Key InChIKey=IQFLDKBWKHEUQY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306427   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306427(2-{1'-[(adamantan-2-yl)carbamoyl]-6-chloro-2,3-dih...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306427(2-{1'-[(adamantan-2-yl)carbamoyl]-6-chloro-2,3-dih...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306427(2-{1'-[(adamantan-2-yl)carbamoyl]-6-chloro-2,3-dih...)
Affinity DataIC50:  30.2nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed