BDBM50319665 (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one::AMG-221::CHEMBL1085107
SMILES CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O
InChI Key InChIKey=YCNCXQNUXCHRRX-ZHPDPMBESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50319665
Affinity DataKi: 12.8nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 12.8nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKi: 70.8nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 11beta-HSD1More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10.1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
Affinity DataIC50: 10.1nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.66nMAssay Description:Inhibition of adipose tissue-derived 11beta-HSD1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair