BDBM50340795 CHEMBL1760686::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-2,5-dimethylfuran-3-carboxamide

SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(C)o1

InChI Key InChIKey=CGWGMYIJFORQBT-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50340795   

LigandChemical structure of BindingDB Monomer ID 50340795BDBM50340795(N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50340795BDBM50340795(N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50340795BDBM50340795(N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50340795BDBM50340795(N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed