BDBM50340822 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N-ethylbenzamide::CHEMBL1760673

SMILES CCNC(=O)c1ccc(cc1)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1

InChI Key InChIKey=ODDNAPFVJHVOLT-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50340822   

LigandPNGBDBM50340822(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340822(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340822(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340822(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340822(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed