BDBM50353128 CHEMBL1231795

SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)C1CCCCC1

InChI Key InChIKey=QOECJCJVIMVJGX-UHFFFAOYSA-N

Data  3 KI  35 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50353128   

TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataKi:  3.70nMAssay Description:Competitive inhibition of G9a (unknown origin) by Morrison plot analysis in presence of histone H3 (1 to 25 residues)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataKi:  3.70nMAssay Description:Competitive inhibition of G9a by fluorescence polarization assay in presence of fluorescein-labeled H3 peptideMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataKi:  18nMAssay Description:Inhibition of G9a (unknown origin) assessed as reduction in substrate methylation using histone H3 and SAM as substrate measured after 15 to 60 mins ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  48nMAssay Description:Inhibition of G9a in human 22Rv1 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  59nMAssay Description:Inhibition of G9a in human PC3 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  70nMAssay Description:Inhibition of G9a in human MCF7 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  81nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  81nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells after 48 hrs by clonogenic assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  81nMAssay Description:Inhibition of G9a in human MCF7 cells after 48 hrs by clonogenic assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  19nMAssay Description:Competitive inhibition of GLP by fluorescence polarization assay in presence of fluorescein-labeled H3 peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  610nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated-histone H3 (1 to 21 residues)/S-adenosyl-methionine as substrate/methyl donor after 3 hrs by Al...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: <15nMAssay Description:Inhibition of G9a (unknown origin) using histone H3 (1 to 25 residues) as substrate preincubated for 2 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  81nMAssay Description:Inhibition of lysine methyltransferase G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell We...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  19nMAssay Description:Inhibition of EHMT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: <15nMAssay Description:Inhibition of EHMT2 (unknown origin)More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  55nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of DNMT1 (unknown origin) by radioactive methyl transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  55nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: <15nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  30nMAssay Description:Inhibition of human G9a using core histone H3 as substrate incubated for 1 hr in presence of [3H]-SAM by filter binding methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: <15nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  13nMAssay Description:Inhibition of N-terminal GST tagged human recombinant EHMT1 (794 to 1294 residues) expressed in baculovirus infected Sf9 insect cells assessed as red...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  26nMAssay Description:Inhibition of N-terminal GST tagged human recombinant EHMT2 (785 to 1210 residues) expressed in baculovirus infected Sf9 insect cells assessed as red...More data for this Ligand-Target Pair
TargetSpindlin-1(Homo sapiens)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of biotin-H3(1-23)K4me3 binding to recombinant human C-terminal His6-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpindlin-1(Homo sapiens)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of FL-H3K4me3 binding to recombinant human C-terminal His6-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 (DE3) cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human G9a using biotinylated-Histone H3 peptide (1 to 21 residues) after 30 mins in presence of SAM by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataKd:  1.42E+3nMAssay Description:Binding affinity to human His-tagged G9a expressed in Escherichia coli Rosetta (DE3) after 30 mins by MST binding assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  19nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  1.07E+5nMAssay Description:Inhibition of N-terminal GST-tagged recombinant full length human DNMT1 (2 to 1632 residues) using poly(dI-dC)):poly(dI-dC) as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  15nMAssay Description:Inhibition G9a (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  15nMAssay Description:Inhibition G9a (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  81nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  210nMAssay Description:Inhibition of G9a in human HCT116 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  12nMAssay Description:Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50:  120nMAssay Description:Inhibition of G9a in human IMR90 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair