BDBM50358204 CHEMBL1922094

SMILES C[C@H](O)C(=O)N1CCN(Cc2sc3c(nc(nc3c2C)-c2cnc(N)nc2)N2CCOCC2)CC1

InChI Key InChIKey=YOVVNQKCSKSHKT-HNNXBMFYSA-N

Data  3 KI  14 IC50  9 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50358204   

LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin) using dioctanoylglycerol-PIP2 as substrate incubated for 30 mins in presence of TAMRA-PIP3 by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant mTOR (1360 to 2549 residues) expressed in insect cells assessed as inhibition of GFP-labeled 4-EBP1 phosphorylation a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  232nMAssay Description:Inhibition of Mlk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  134nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of PIKKC2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of PI3K subunit p110alpha assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  27nMAssay Description:Inhibition of PI3K subunit p110beta assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of PI3K subunit p110delta assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  794nMAssay Description:Inhibition of PIKKC2beta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 40 mins by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI4KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI4KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  580nMAssay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  9.80E+3nMAssay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human mTOR (L1382 to W2549 residues) expressed in mammalian expression system at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human PI4KCbeta (M1 to M828 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  250nMAssay Description:Binding affinity to human VPS34 (S282 to H879 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  0.620nMAssay Description:Binding affinity to human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  697nMAssay Description:Inhibition of FgrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of VPS34 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed