BDBM50358204 CHEMBL1922094

SMILES C[C@H](O)C(=O)N1CCN(Cc2sc3c(nc(nc3c2C)-c2cnc(N)nc2)N2CCOCC2)CC1

InChI Key InChIKey=YOVVNQKCSKSHKT-HNNXBMFYSA-N

Data  3 KI  14 IC50  9 Kd

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50358204   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  232nMAssay Description:Inhibition of Mlk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  134nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of PIKKC2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of PI3K subunit p110alpha assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  27nMAssay Description:Inhibition of PI3K subunit p110beta assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of PI3K subunit p110delta assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  794nMAssay Description:Inhibition of PIKKC2beta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI4KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI4KbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  697nMAssay Description:Inhibition of FgrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of VPS34 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed