BDBM50370572 CHEMBL85606::SB-277011
SMILES O=C(N[C@H]1CC[C@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c1ccnc2ccccc12
InChI Key InChIKey=OLWRVVHPJFLNPW-LSNLESRRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50370572
Affinity DataKi: 3.98nMAssay Description:Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.98nMAssay Description:Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.98nMAssay Description:Binding affinity to human DRD3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells after 90 mins by [35S]-GTPgamma S assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of [125I]-7-OH-PIPAT from rat brain dopamine D3 receptor after 45 mins by microplate scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity towards human Dopamine receptor D3 by displacement of [125I]iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 10.7nMAssay Description:Inhibition of [125I]-iodosulpiride binding to rat Dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 11.2nMAssay Description:Inhibition of [125I]iodosulpiride binding to human Dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 398nMAssay Description:Binding affinity to human DRD2 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 398nMAssay Description:Antagonist activity at dopamine D2 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 398nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 490nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes coexpressing Galpha16 after 120 mins by liquid scin...More data for this Ligand-Target Pair
Affinity DataKi: 501nMAssay Description:Displacement of [125I]-7-OH-PIPAT from rat brain dopamine D2 receptor after 45 mins by microplate scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 501nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
Affinity DataKi: 631nMAssay Description:Antagonist activity at histamine H1 receptor by FLIPR assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataKi: 631nMAssay Description:Displacement of [125I]-7-OH-PIPAT from rat brain dopamine D3 receptor after 45 mins by microplate scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Binding affinity towards human Dopamine receptor D2 by displacement of [125I]iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D2 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.05E+3nMAssay Description:Inhibition of [125I]iodosulpiride binding to human Dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 2.82E+3nMAssay Description:Inhibition of [125I]iodosulpiride binding to rat Dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.16E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO cells after 90 mins by [35S]-GTPgamma S assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in CHO cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]Dofetilide from human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 631nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 676nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetidile from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aptuit
Curated by ChEMBL
Aptuit
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair