BDBM50514950 CHEMBL4524886::US10988478, Example 152

SMILES CN1CCC2(Cc3cc(NC(=O)c4cnn5cccnc45)c(cc3O2)N2CCOCC2)CC1

InChI Key InChIKey=VAFIUWXLNRDXHB-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514950   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50514950(CHEMBL4524886 | US10988478, Example 152)
Affinity DataKi:  7.40nMAssay Description:Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50514950(CHEMBL4524886 | US10988478, Example 152)
Affinity DataKi:  12nMAssay Description:Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50514950(CHEMBL4524886 | US10988478, Example 152)
Affinity DataIC50:  230nMAssay Description:Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed