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BDBM545525 US11286268, Compound 1016

SMILES: CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(-c4ccccc4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=SYMQDVBRSHHIJO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545525   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545525
PNG
(US11286268, Compound 1016)
Show SMILES CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(-c4ccccc4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H24ClN5O4S/c1-3-21-14-23(31-30(38-21)25(17-44-31)33(41)42)22-13-20(34)9-10-27(22)43-12-11-39-18(2)37-26-16-36-29(19-7-5-4-6-8-19)24(15-35)28(26)32(39)40/h4-10,13-14,16-17H,3,11-12H2,1-2H3,(H,41,42)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.11n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair