BDBM6645 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid::CHEMBL341824::Pteridine deriv. 12

SMILES Nc1nc2ncc(CNc3ccc(cc3)C(O)=O)nc2c(=O)[nH]1

InChI Key InChIKey=JOAQINSXLLMRCV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6645   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM6645(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}b...)
Show SMILES Nc1nc2ncc(CNc3ccc(cc3)C(O)=O)nc2c(=O)[nH]1
Show InChI InChI=1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)
Affinity DataIC50: 1.60E+4nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...More data for this Ligand-Target Pair
TargetRicin(Ricinus communis)
Toho University

Curated by ChEMBL
LigandPNGBDBM6645(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}b...)
Show SMILES Nc1nc2ncc(CNc3ccc(cc3)C(O)=O)nc2c(=O)[nH]1
Show InChI InChI=1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of Ricin toxin AMore data for this Ligand-Target Pair
TargetRicin(Ricinus communis)
Toho University

Curated by ChEMBL
LigandPNGBDBM6645(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}b...)
Show SMILES Nc1nc2ncc(CNc3ccc(cc3)C(O)=O)nc2c(=O)[nH]1
Show InChI InChI=1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomesMore data for this Ligand-Target Pair
TargetRicin(Ricinus communis)
Toho University

Curated by ChEMBL
LigandPNGBDBM6645(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}b...)
Show SMILES Nc1nc2ncc(CNc3ccc(cc3)C(O)=O)nc2c(=O)[nH]1
Show InChI InChI=1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of castor seed ricin A chain translation degradation activity in rabbit reticulocyte lysate after 90 mins by luciferase-based luminometer ...More data for this Ligand-Target Pair