BDBM7459 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL151::Luteolin (27)::Luteolin (4)::acs.jmedchem.1c00409_ST.600::cid_5280445::luteolin::med.21724, Compound 3

SMILES: c1cc(c(cc1C2=CC(=O)c3c(cc(cc3O2)O)O)O)O

InChI Key: InChIKey=IQPNAANSBPBGFQ-UHFFFAOYSA-N

Data: 27 KI  137 IC50  2 Kd  13 EC50  1 ITC

PDB links: 15 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 179 hits for monomerid = 7459   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin homolog/dependent kinase 6 (Human-SaHV-2)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.0	30
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Cyclin-dependent kinase 5 activator 1 [99-307] (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	7.0	30
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Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Spiny starfish)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	7.0	30
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Glycogen synthase kinase-3 beta (Rat)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	30
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Seed linoleate 13S-lipoxygenase-1 (Soybean)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-amylase 1A (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.84E+4	n/a	n/a	n/a	n/a	6.0	22
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Serine/threonine-protein kinase pim-1 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.0	30
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Zinc finger protein mex-5 (Caenorhabditis elegans)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a
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POsterior Segregation (Caenorhabditis elegans)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.04E+4	n/a	n/a	n/a	n/a
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M1 family aminopeptidase (Plasmodium falciparum (isolate FcB1 / Columbia))	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Large T antigen (SV40)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.79E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Glycogen synthase kinase-3 beta (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.81E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	37
TBA									Citation and Details
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Mitogen-activated protein kinase 10 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	37
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PC4 and SFRS1-interacting protein (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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PC4 and SFRS1-interacting protein (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
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1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli (strain K12))	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Aurora kinase B (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Dipeptidyl peptidase 3 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
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Fatty acid synthase (Chicken)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.25E+4	n/a	n/a	n/a	n/a	7.0	37
TBA									Citation and Details
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Interstitial collagenase [100-268] (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.03E+3	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (SARS-CoV)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Spike glycoprotein [668-1255] (SARS-CoV)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (SARS-CoV)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Homeobox protein Nkx-2.5/Transcription factor GATA-4 (Mouse)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cytochrome P450 1B1 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Xanthine dehydrogenase/oxidase (Bovine)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Neutrophil elastase (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histidine kinase (Streptococcus pneumoniae PCS8203)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Chemotaxis protein CheA (Escherichia coli (strain K12))	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Dipeptidyl peptidase 4 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Enoyl-acyl-carrier protein reductase (malaria parasite P. falciparum)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (SARS-CoV)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Alpha-glucosidase MAL62 (Baker's yeast)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Lysosomal alpha-glucosidase (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Aldo-keto reductase family 1 member B1 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Aldo-keto reductase family 1 member B10 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member B10 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine protease 1 (Bovine)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Nonstructural protein 3 (ZIKV)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Inositol polyphosphate multikinase (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Inositol hexakisphosphate kinase 2 (Human)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 7459

Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
Transcriptional Regulator TtgR (Pseudomonas putida)	BDBM7459 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)	GoogleScholar			-7.12	-4.08	-3.05	5.14	7	30
TBA					Details of this binding reaction