BDBM8046 (4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-yl]amine::2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 17::4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(4-fluorophenyl)pyrimidin-2-amine::CS14

SMILES: Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(F)cc2)n1

InChI Key: InChIKey=PKHXJWYQMRFPTR-UHFFFAOYSA-N

Data: 2 KI  5 Kd  2 K_off  2 K_on

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 8046   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.78E+3	n/a	n/a	n/a	7.5	25
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Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.43E+3	n/a	n/a	n/a	7.5	25
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	121	n/a	n/a	n/a	7.5	25
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	2.42E+5	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	0.0290	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.43E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	n/a	6.43E+4	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	n/a	0.0770	n/a	n/a	n/a
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		40	-10.3	n/a	n/a	n/a	n/a	n/a	7.4	30
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM8046 ((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	>-6.51	n/a	n/a	n/a	n/a	n/a	n/a	30
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					More data for this Ligand-Target Pair