BDBM84991 CAS_3277600::NSC_3277600::SB204741

SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI Key InChIKey=USFUFHFQWXDVMH-UHFFFAOYSA-N

Data  31 KI  1 Kd

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 84991   

Target5-hydroxytryptamine receptor 2B(RAT)
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  15.8nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(RAT)
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  50.1nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  51.3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  126nMMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(PIG)
Friedrich-Schiller-University Jena

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(RAT)
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(PIG)
Friedrich-Schiller-University Jena

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Mus musculus (Mouse))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  1.51E+3nMAssay Description:Binding affinity analysed on 5-HT 2C in human clone using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  2.14E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  2.75E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >6.31E+3nMAssay Description:Binding affinity analysed on 5-HT 2A human clone using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 4(PIGLET)
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(RAT)
SmithKline Beecham Pharmaceuticals Ltd

Curated by PDSP Ki Database
LigandPNGBDBM84991(CAS_3277600 | NSC_3277600 | SB204741)
Show SMILES Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
Show InChI InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
Affinity DataKd:  11.2nMAssay Description:Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusMore data for this Ligand-Target Pair