BDBM8813 3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-methylphenyl)urea::CHEMBL371329::CHEMBL537435::KDR Kinase Inhibitor, 7::N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-phenyl]-N -(3-methylphenyl)urea::Thienopyrimidine deriv. 11

SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1

InChI Key InChIKey=UKICZFWMZQMZGK-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 8813   

TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 6nMAssay Description:Inhibition assay using KDR.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 6nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 6nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 6.03nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 8.91nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 9nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Tie2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8813(CHEMBL537435 | KDR Kinase Inhibitor, 7 | CHEMBL371...)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed