BDBM93421 PHD Inhibitor, 12{1,5,3}

SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O

InChI Key InChIKey=YGWDELLSCZJHOC-KYJUHHDHSA-N

Data  3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 93421   

TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93421(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/m0/s1
Affinity DataIC50: 2.92E+3nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93421(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/m0/s1
Affinity DataIC50: 165nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93421(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/m0/s1
Affinity DataIC50: 95nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair