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Found 2216 with Last Name = 'al-awar' and Initial = 'r'
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  38nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50396981(CHEMBL2171174)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  750nMAssay Description:Inhibition of recombinant full length human NNMT measured for 30 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  950nMAssay Description:Inhibition of DNMT1 (unknown origin) using [3H]-SAM assessed as inhibition of dsDNA methylation after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto At Mississauga

Curated by ChEMBL
LigandPNGBDBM50446146(CHEMBL3108909)
Affinity DataKi:  1.00E+4nMAssay Description:Competitive binding affinity to STAT3 SH2 domain (unknown origin) assessed as inhibition of interaction with FAMpYLPQTV after 15 to 30 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto At Mississauga

Curated by ChEMBL
LigandPNGBDBM50446144(CHEMBL3108911)
Affinity DataKi:  1.00E+4nMAssay Description:Competitive binding affinity to STAT3 SH2 domain (unknown origin) assessed as inhibition of interaction with FAMpYLPQTV after 15 to 30 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto At Mississauga

Curated by ChEMBL
LigandPNGBDBM50446145(CHEMBL3108910)
Affinity DataKi:  1.00E+4nMAssay Description:Competitive binding affinity to STAT3 SH2 domain (unknown origin) assessed as inhibition of interaction with FAMpYLPQTV after 15 to 30 mins by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50396023(CHEMBL2169919)
Affinity DataIC50:  0.400nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 416 amino acid residues) using [3H]-SAM assessed as inhibition of nucleosome methylation incu...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of SUMO-His-tagged WDR5 (unknown origin) interaction with MLL1 assessed as displacement of fluorescence labelled Ac-ARA peptide substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50: <2nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6745(1,7-Annulated indolocarbazole deriv. 13Ab | 7-fluo...)
Affinity DataIC50:  2nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528203(CHEMBL4434694)
Affinity DataIC50: <2nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50: <2nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) interaction with MLL1 assessed as displacement of 5-Lys-FAM peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528196(CHEMBL4575655)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544399(CHEMBL4638273)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528209(CHEMBL4526828)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528190(CHEMBL4548795)
Affinity DataIC50:  3nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50: <3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50566950(CHEMBL4852125)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50566949(CHEMBL4877302)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human GRK6 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528208(CHEMBL4440168)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544408(CHEMBL4641207)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528203(CHEMBL4434694)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT8 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT3 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT4 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT6 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528190(CHEMBL4548795)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528205(CHEMBL4468389)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528204(CHEMBL4565968)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544414(CHEMBL4641530)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528203(CHEMBL4434694)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50:  5nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528190(CHEMBL4548795)
Affinity DataIC50:  6nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528190(CHEMBL4548795)
Affinity DataIC50:  6nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50:  6nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 G328V mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50566953(CHEMBL4860332)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544419(CHEMBL4647724)
Affinity DataIC50:  6nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544418(CHEMBL4648102)
Affinity DataIC50:  6nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK7(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50566949(CHEMBL4877302)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of recombinant full length human GRK7 using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50:  7nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 Q207D mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544404(CHEMBL4644571)
Affinity DataIC50:  7nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544413(CHEMBL4633241)
Affinity DataIC50:  7nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528208(CHEMBL4440168)
Affinity DataIC50:  7nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50566946(CHEMBL4854871)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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