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Found 750 with Last Name = 'cregar' and Initial = 'l'
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379543(CHEMBL2012752)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329261((R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluo...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329261((R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluo...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218667(APC-1390 | CHEMBL46809)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.0780nMAssay Description:Binding affinity for factor VIIa/TFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093175(CHEMBL311655 | Derivative of APC-2059)
Affinity DataKi:  0.100nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093157(CHEMBL431969 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.100nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379542(CHEMBL2012753)
Affinity DataKi:  0.110nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379536(CHEMBL2012836)
Affinity DataKi:  0.170nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093192(CHEMBL311482 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.200nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379541(CHEMBL2012832)
Affinity DataKi:  0.230nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329265((R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluo...)
Affinity DataKi:  0.240nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329265((R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluo...)
Affinity DataKi:  0.240nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329265((R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluo...)
Affinity DataKi:  0.240nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340755((S)-2-(4-fluoro-3-methylbenzyl)-6-(4-fluorobenzyla...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379533(CHEMBL2012838)
Affinity DataKi:  0.270nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379540(CHEMBL2012750)
Affinity DataKi:  0.300nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329270((R)-2-(4-fluoro-3,5-dimethylphenylamino)-N-hydroxy...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379535(CHEMBL2010824)
Affinity DataKi:  0.310nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340756((S)-6-(4-chlorobenzylamino)-2-(4-fluoro-3-methylbe...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340757((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-...)
Affinity DataKi:  0.390nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093167(CHEMBL75750 | Derivative of APC-2059)
Affinity DataKi:  0.400nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093156(CHEMBL432172 | Derivative of APC-2059)
Affinity DataKi:  0.400nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093154(CHEMBL448786 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.400nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101018(1,4-di{4-[4-amino(imino)methylphenylcarboxamidomet...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329267((R)-2-(4-fluoro-3,5-dimethylphenylamino)-N-hydroxy...)
Affinity DataKi:  0.410nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329268((R)-2-(4-fluoro-3,5-dimethylphenylamino)-N-hydroxy...)
Affinity DataKi:  0.440nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity of the compound towards urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329269((R)-2-(4-fluoro-3,5-dimethylphenylamino)-N-hydroxy...)
Affinity DataKi:  0.470nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379544(CHEMBL2012751)
Affinity DataKi:  0.490nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218668(CHEMBL42900)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101882(CHEMBL53829 | Phosphoric acid mono-{2-[3-(3-benzyl...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101871(3-[3-(3-Benzyl-5-carbamimidoyl-1H-indol-2-yl)-5-br...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093199(CHEMBL75972 | Derivative of APC-2059)
Affinity DataKi:  0.5nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103651(2-(3'-Amino-5-chloro-2-hydroxy-biphenyl-3-yl)-1H-b...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound towards Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093173(CHEMBL309830 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.5nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093158(1-{4-[4-amino(imino)methylaminobenzylcarbamoyl]hex...)
Affinity DataKi:  0.5nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50379539(CHEMBL2012834)
Affinity DataKi:  0.600nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340759((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3...)
Affinity DataKi:  0.620nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340760((R)-6-(4-chlorobenzylamino)-2-(4-fluoro-3-methylph...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50329263((R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(2-fluo...)
Affinity DataKi:  0.690nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101881(4-[3-(3-Benzyl-5-carbamimidoyl-1H-indol-2-yl)-5-br...)
Affinity DataKi:  0.700nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093178(CHEMBL76883 | Derivative of APC-2059)
Affinity DataKi:  0.700nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340761((S)-6-(4-chlorobenzylamino)-2-(4-fluoro-3,5-dimeth...)
Affinity DataKi:  0.710nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340762((R)-6-(4-chlorobenzylamino)-2-(4-fluoro-3-methylph...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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