BDBM50084616 CHEMBL310290::[(4-Aminomethyl-benzylcarbamoyl)-methyl]-carbamic acid 4-[(4-aminomethyl-benzylcarbamoyl)-methylcarbamoyloxymethyl]-benzyl ester

SMILES NCc1ccc(CNC(=O)CNC(=O)OCc2ccc(COC(=O)NCC(=O)NCc3ccc(CN)cc3)cc2)cc1

InChI Key InChIKey=IEDBGWNXIHURPN-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50084616   

TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi:  8.40E+4nMAssay Description:Inhibitory potency against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi:  8.40E+4nMAssay Description:Binding affinity against TrypsinChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory potency against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory potency against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed