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Found 274 with Last Name = 'horner' and Initial = 'm'

Sphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)

IC50: 0.280nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM22209(1,2,4-oxadiazole based compound, 26 | 1-[(4-{5-[4-...)

IC50: 0.600nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463853(CHEMBL4237618)

IC50: 5nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463844(CHEMBL4247840)

IC50: 6nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463854(CHEMBL4251427)

IC50: 6nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)

IC50: 6.30nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463853(CHEMBL4237618)

IC50: 7nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463844(CHEMBL4247840)

IC50: 8nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM22203(1,2,4-oxadiazole based compound, 13 | 1-({4-[3-(4-...)

IC50: 8.20nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463846(CHEMBL4243837)

IC50: 9nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463846(CHEMBL4243837)

IC50: 9nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM22203(1,2,4-oxadiazole based compound, 13 | 1-({4-[3-(4-...)

IC50: >10nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM22201(1,3,4-oxadiazole based compound, 9 | 1-({4-[5-(4-t...)

IC50: >10nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463863(CHEMBL4251467)

IC50: 10nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463855(CHEMBL4248077)

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Sphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)

IC50: >10nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM22209(1,2,4-oxadiazole based compound, 26 | 1-[(4-{5-[4-...)

IC50: 12nMAssay Description:Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463846(CHEMBL4243837)

IC50: 12nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463854(CHEMBL4251427)

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463850(CHEMBL4241349)

IC50: 13nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463863(CHEMBL4251467)

IC50: 13nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463876(CHEMBL4238921)

IC50: 15nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463855(CHEMBL4248077)

IC50: 15nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463863(CHEMBL4251467)

IC50: 17nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463859(CHEMBL4245257)

IC50: 18nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463858(CHEMBL4246904)

IC50: 19nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463862(CHEMBL4248426)

IC50: 20nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463850(CHEMBL4241349)

IC50: 20nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463849(CHEMBL4250626)

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463855(CHEMBL4248077)

IC50: 21nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463844(CHEMBL4247840)

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463875(CHEMBL4242867)

IC50: 22nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463876(CHEMBL4238921)

IC50: 24nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463868(CHEMBL4247268)

IC50: 27nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463854(CHEMBL4251427)

IC50: 27nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463856(CHEMBL4247395)

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463849(CHEMBL4250626)

IC50: 30nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL

BDBM50463859(CHEMBL4245257)

IC50: 34nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463867(CHEMBL4249999)

IC50: 35nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Sphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50158345(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)

IC50: 37nMAssay Description:Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranesMore data for this Ligand-Target Pair

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3D Structure (crystal)

Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463868(CHEMBL4247268)

IC50: 40nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463856(CHEMBL4247395)

IC50: 43nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463858(CHEMBL4246904)

IC50: 49nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463851(CHEMBL4237740)

IC50: 51nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463859(CHEMBL4245257)

IC50: 53nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463867(CHEMBL4249999)

IC50: 54nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463865(CHEMBL4244629)

IC50: 59nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Mus musculus)
TBA

Curated by ChEMBL

BDBM50463875(CHEMBL4242867)

IC50: 67nMAssay Description:Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463872(CHEMBL4246304)

IC50: 75nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...More data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50463848(CHEMBL4245611)

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Displayed 1 to 50 (of 274 total ) | Next | Last >>

Filter my 274 hits

Targets 13▿
- Sphingosine 1-phosphate receptor 1 108
- Sphingosine 1-phosphate receptor 3 82
- Transient receptor potential cation channel subfamily M member 8 71
- Potassium voltage-gated channel subfamily H member 2 3
- Sphingosine 1-phosphate receptor 5 2
- Transient receptor potential cation channel subfamily V member 4 1
- Transient receptor potential cation channel subfamily V member 3 1
- Sphingosine 1-phosphate receptor 4 1
- Transient receptor potential cation channel subfamily V member 1 1
- Transient receptor potential cation channel subfamily A member 1 1
- Cytochrome P450 2D6 1
- Sphingosine 1-phosphate receptor 2 1
- Cytochrome P450 3A4 1
- ...
Publications 6▿
- J Med Chem 61: 8186-8201 (2018) 75
- ACS Med Chem Lett 2: 97-101 (2011) 65
- ACS Med Chem Lett 2: 102-106 (2011) 47
- Bioorg Med Chem Lett 22: 527-31 (2011) 37
- ACS Med Chem Lett 2: 107-112 (2011) 32
- ACS Med Chem Lett 2: 752-757 (2011) 18
Institutions 2▿
- TBA 237
- Amgen 37
Affinity: 0.28 to 5.0E+4 nM▿
- IC50 90
- EC50 184
- Affinity ≤ nM
Xtal structures: 3
Docked structures: 0
Catalog Cmpds: 10