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Found 2088 with Last Name = 'kisliuk' and Initial = 'rl'
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataKi:  0.00210nMAssay Description:Tested for inhibition of dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50016323(2-{4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin...)
Affinity DataKi:  0.00212nMAssay Description:Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataKi:  0.00230nMAssay Description:Tested for inhibition of dihydrofolate reductase enzyme from mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50025009(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-1-methyl-ethyl...)
Affinity DataKi:  0.00240nMAssay Description:Tested for inhibition of dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50028641(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-1,1-dimethyl-e...)
Affinity DataKi:  0.00260nMAssay Description:Tested for inhibition of dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50016324(2-{4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin...)
Affinity DataKi:  0.00264nMAssay Description:Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50016460((S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-prop...)
Affinity DataKi:  0.00280nMAssay Description:Concentration of the compound inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50004544(2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-...)
Affinity DataKi:  0.00280nMAssay Description:Tested for inhibition of dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50016326(2-{4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin...)
Affinity DataKi:  0.00293nMAssay Description:Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50405400(CHEMBL2051987)
Affinity DataKi:  0.00300nMAssay Description:Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50405400(CHEMBL2051987)
Affinity DataKi:  0.00300nMAssay Description:Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50028605(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-propyl-ami...)
Affinity DataKi:  0.00300nMAssay Description:In vitro inhibitory activity against L1210 dihydrofolate reductase in rodent neoplastic cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00320nMAssay Description:Tested for inhibition of dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataKi:  0.00340nMAssay Description:Concentration of the compound inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataKi:  0.00355nMAssay Description:Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50016325(2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmeth...)
Affinity DataKi:  0.00365nMAssay Description:Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00400nMAssay Description:Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50226274(CHEMBL3349020)
Affinity DataKi:  0.00400nMAssay Description:Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataKi:  0.00400nMAssay Description:In vitro inhibitory activity against L1210 dihydrofolate reductase in rodent neoplastic cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50014707(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-propyl]-benzoy...)
Affinity DataKi:  0.00520nMAssay Description:Concentration of the compound inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50016322(2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmeth...)
Affinity DataKi:  0.00530nMAssay Description:Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00545nMAssay Description:Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00548nMAssay Description:Compound was evaluated for inhibitory effect on dihydrofolate reductase (DHFR) from L1210 cells at Inhibitory constant (n=3)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50014706(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoyl...)
Affinity DataKi:  0.00550nMAssay Description:Concentration of the compound inhibiting Dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00600nMAssay Description:Inhibitory activity of Dihydrofolate reductase derived from L1210 cell line.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00600nMAssay Description:In vitro inhibitory activity against L1210 dihydrofolate reductase in rodent neoplastic cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50008287(2-{4-[2-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-yl)-...)
Affinity DataKi:  0.00700nMAssay Description:Inhibitory activity of Dihydrofolate reductase derived from L1210 cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50405401(CHEMBL2051990)
Affinity DataKi:  0.0120nMAssay Description:Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50008285(2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylme...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory activity of Dihydrofolate reductase derived from L1210 cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50022738(2-{4-[2-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimid...)
Affinity DataKi:  0.0283nMAssay Description:Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50040861((S)-2-(5-(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUIN...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of TS by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50028603(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-prop-2-yny...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibitory activity against L1210 dihydrofolate reductase in rodent neoplastic cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50022740(2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4-dihydro-pyrido...)
Affinity DataKi: >1nMAssay Description:Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataKi: >1nMAssay Description:Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50022739((6RS) 2-{4-[2-(2-Amino-5-ethyl-4-oxo-3,4,5,6,7,8-h...)
Affinity DataKi: >1nMAssay Description:Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataKi:  7nMpH: 7.4Assay Description:Inhibition of recombinant human dihydrofolate reductase done at 37 degree C in pH 7.4 with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50028604(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-octyl-amin...)
Affinity DataKi:  18nMAssay Description:In vitro inhibitory activity against L1210 dihydrofolate reductase in rodent neoplastic cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataKi:  340nMpH: 7.4Assay Description:Inhibition of human thymidylate synthetase at 37 degree C pH 7.4More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50016460((S)-2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-prop...)
Affinity DataKi:  990nMAssay Description:Binding affinity of the compound towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50014935(2-{4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity of Dihydrofolate reductase derived from L1210 cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50024475(2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-quinazo...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity of Dihydrofolate reductase derived from L1210 cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50014936(2-{4-[1-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyri...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity of Dihydrofolate reductase derived from L1210 cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity of the compound towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50014707(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-propyl]-benzoy...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory activity of the compound towards Dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity of the compound towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity of the compound towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50014706(2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoyl...)
Affinity DataKi:  8.20E+3nMAssay Description:Inhibitory activity of the compound towards Dihydrofolate reductase derived from human manca leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50226275(CHEMBL267104)
Affinity DataIC50:  0nMAssay Description:Compound was evaluated for inhibitory effect on the dihydrofolate reductase (DHFR) of Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50226275(CHEMBL267104)
Affinity DataIC50:  0nMAssay Description:Compound was evaluated for inhibitory effect on the thymidylate synthase (TS) of Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50016658(2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pteri...)
Affinity DataIC50:  0nMAssay Description:Inhibition of the GAR transformylase in lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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