TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.00400nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: <0.100nMAssay Description:Binding affinity against human leukocyte ElastaseMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1(Homo sapiens (Human))
Merrell Dow Research Institute
Curated by ChEMBL
Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.580nMAssay Description:Binding affinity against human ElastaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Compound was evaluated In vitro for inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1(Homo sapiens (Human))
Merrell Dow Research Institute
Curated by ChEMBL
Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Binding affinity against human ElastaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Tested for rate of substrate hydrolysis in the presence of human neutrophil elastaseMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:The compound was tested for its potency to inhibit human neutrophil elastase activityMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Binding affinity against human Elastase for more active diasteriomerMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Binding affinity against human Elastase for more active diasteriomerMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: >7nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Compound was evaluated In vitro for inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibitory activity against chicken gizzard smooth muscle calpainMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Tested for inhibition of substrate hydrolysis in the presence of porcine kidney esterase at a concentration of 10 nMMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:pA2 value towards endothelin receptor A was determined as functional ETA antagonismMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Compound was evaluated In vitro for inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Merrell Dow Research Institute
Curated by ChEMBL
Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Binding affinity for porcine ElastaseMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:The compound was tested for its potency to inhibit human neutrophil elastase activityMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity against alpha-chymotrypsinMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair