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Found 187 with Last Name = 'mehdi' and Initial = 's'
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044868(7-(1-Carboxy-3-phenyl-propylamino)-6-oxo-1,2,3,4,6...)
Affinity DataKi:  0.00400nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50175518((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)
Affinity DataKi:  0.0700nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50228471(CHEMBL131548)
Affinity DataKi: <0.100nMAssay Description:Binding affinity against human leukocyte ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287694(3-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287702((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287689(CHEMBL304233 | [(2-Mercaptomethyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50289194((S)-2-[(S)-4-((R)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataKi:  0.400nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287700((S)-3-(4-Hydroxy-phenyl)-2-[(2-mercaptomethyl-1,2,...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035500((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014738(CHEMBL130253 | N-(Adamantyl-sulfonyl)-N-(methoxy s...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity against human ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287699(4-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287690(7-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014735((1-{1-Methyl-2-oxo-2-[2-(3,3,3-trifluoro-1-isoprop...)
Affinity DataKi:  1nMAssay Description:Compound was evaluated In vitro for inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like elastase family member 1(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014735((1-{1-Methyl-2-oxo-2-[2-(3,3,3-trifluoro-1-isoprop...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024096(((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50024096(((R)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataKi:  2nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287696((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  2nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50069667((S)-3-{[1-((S)-2-{(S)-2-[4-(4-Chloro-benzenesulfon...)
Affinity DataKi:  2nMAssay Description:Tested for rate of substrate hydrolysis in the presence of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044869(7-(2-Mercapto-acetylamino)-6-oxo-1,2,3,4,6,7,8,12b...)
Affinity DataKi:  2nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044867(7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-octahydro...)
Affinity DataKi:  2nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035528(Acetic acid (E)-2-[((S)-1-{(S)-2-[4-(4-chloro-benz...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50281590(CHEMBL150384 | N-(1-Benzyl-3,3,3-trifluoro-2-oxo-p...)
Affinity DataKi:  4nMAssay Description:The compound was tested for its potency to inhibit human neutrophil elastase activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287695((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  4nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287701((4S,7S)-7-(2-Mercapto-acetylamino)-6-oxo-1,2,3,4,6...)
Affinity DataKi:  5nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50044869(7-(2-Mercapto-acetylamino)-6-oxo-1,2,3,4,6,7,8,12b...)
Affinity DataKi:  5nMAssay Description:Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014732(1-{2-[2-(5-Dimethylamino-naphthalene-1-sulfonylami...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity against human Elastase for more active diasteriomerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014730(CHEMBL130271 | N-(1-{1-Methyl-2-oxo-2-[2-(3,3,3-tr...)
Affinity DataKi:  7nMAssay Description:Binding affinity against human Elastase for more active diasteriomerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287693((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Affinity DataKi:  7nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044867(7-Mercaptomethyl-6-oxo-1,2,3,4,6,7,8,12b-octahydro...)
Affinity DataKi: >7nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287692(CHEMBL431957 | [(2-Mercaptomethyl-indane-2-carbony...)
Affinity DataKi:  10nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014732(1-{2-[2-(5-Dimethylamino-naphthalene-1-sulfonylami...)
Affinity DataKi:  10nMAssay Description:Compound was evaluated In vitro for inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Gallus gallus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against chicken gizzard smooth muscle calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035498((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  12nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-formylglutathione hydrolase(Sus scrofa)
Cinc

Curated by ChEMBL
LigandPNGBDBM50069665((E)-2-Acetoxy-3-{[(S)-1-((S)-2-{(S)-2-[4-(4-chloro...)
Affinity DataKi:  13nMAssay Description:Tested for inhibition of substrate hydrolysis in the presence of porcine kidney esterase at a concentration of 10 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-formylglutathione hydrolase(Sus scrofa)
Cinc

Curated by ChEMBL
LigandPNGBDBM50069665((E)-2-Acetoxy-3-{[(S)-1-((S)-2-{(S)-2-[4-(4-chloro...)
Affinity DataKi:  13nMAssay Description:pA2 value towards endothelin receptor A was determined as functional ETA antagonismMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014730(CHEMBL130271 | N-(1-{1-Methyl-2-oxo-2-[2-(3,3,3-tr...)
Affinity DataKi:  14nMAssay Description:Compound was evaluated In vitro for inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50287691(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalene-2-...)
Affinity DataKi:  14nMAssay Description:Inhibition of neutral endopeptidase(NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014738(CHEMBL130253 | N-(Adamantyl-sulfonyl)-N-(methoxy s...)
Affinity DataKi:  15nMAssay Description:Binding affinity for porcine ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50281589(5N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)-1-[3-met...)
Affinity DataKi:  16nMAssay Description:The compound was tested for its potency to inhibit human neutrophil elastase activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035535(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014743(CHEMBL132171 | N-(1-{2-[2-(1-Benzyl-3,3,3-trifluor...)
Affinity DataKi:  17nMAssay Description:Binding affinity against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065147((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  18nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50065158((R)-4-Benzyloxy-1-{(S)-3-methyl-2-[4-(morpholine-4...)
Affinity DataKi:  20nMAssay Description:Inhibition of human neutrophil elastase in hamster lungs following 25 mg/kg pre-treatment before instillation of elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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