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Found 195 with Last Name = 'pavia' and Initial = 'mr'
LigandPNGBDBM50280565(5-(1-Aza-bicyclo[2.2.1]hept-3-yl)-[1,2,4]oxadiazol...)
Affinity DataIC50:  0.300nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50065213(1-Aza-bicyclo[2.2.1]heptan-3-one O-prop-2-ynyl-oxi...)
Affinity DataIC50:  3.5nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280560(1-Aza-bicyclo[2.2.1]heptan-3-one O-pent-2-ynyl-oxi...)
Affinity DataIC50:  3.60nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280567(1-Aza-bicyclo[2.2.1]heptan-3-one O-but-2-ynyl-oxim...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50009300(CHEMBL11081 | N-Methyl-N-(4-pyrrolidin-1-yl-but-2-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataIC50:  6.70nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50065210(1-Aza-bicyclo[2.2.1]heptan-3-one O-nona-2,5,8-triy...)
Affinity DataIC50:  8nMAssay Description:Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280559(1-Aza-bicyclo[2.2.1]heptan-3-one O-ethyl-oxime | C...)
Affinity DataIC50:  13nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50065215(1-Aza-bicyclo[2.2.1]heptan-3-one O-methyl-oxime | ...)
Affinity DataIC50:  18nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50280565(5-(1-Aza-bicyclo[2.2.1]hept-3-yl)-[1,2,4]oxadiazol...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280524(2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime | CHEM...)
Affinity DataIC50:  21nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50009291(CHEMBL75358 | N-(4-Dimethylamino-but-2-ynyl)-N-met...)
Affinity DataIC50:  22nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50065205(1-Aza-bicyclo[2.2.1]heptan-3-one O-hexa-2,5-diynyl...)
Affinity DataIC50:  22nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50006584((McN-A-343) [4-(3-Chloro-phenylcarbamoyloxy)-but-2...)
Affinity DataIC50:  25nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280522(6-Dimethylamino-2-methyl-hex-4-ynal oxime | CHEMBL...)
Affinity DataIC50:  30nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280573(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-5-en-2-ynyl...)
Affinity DataIC50:  32nMAssay Description:Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50065209((3Z)-1-azabicyclo[2.2.1]heptan-3-oneO-[(2E)-pent-2...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280561(1-Aza-bicyclo[2.2.1]heptan-3-one O-(1-methyl-prop-...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280562(1-Aza-bicyclo[2.2.1]heptan-3-one O-hepta-2,5-diyny...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50008064((S)-3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)-ox...)
Affinity DataIC50:  43nMAssay Description:Compound was evaluated for its ability to displace muscarinic agonist [3H]quinuclidinyl benzilate in rat cortical tissue (RCMD binding assay), at 0.1...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280575(1-Aza-bicyclo[2.2.1]heptan-3-one O-hept-2-ynyl-oxi...)
Affinity DataIC50:  44nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280570(1-Aza-bicyclo[2.2.1]heptan-3-one O-isopropyl-oxime...)
Affinity DataIC50:  46nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50065227(1-Aza-bicyclo[2.2.1]heptan-3-one O-(3-phenyl-prop-...)
Affinity DataIC50:  46nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280566(1-Aza-bicyclo[2.2.1]heptan-3-one O-hex-2-ynyl-oxim...)
Affinity DataIC50:  48nMAssay Description:Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280563(1-Aza-bicyclo[2.2.1]heptan-3-one O-(4-methoxy-but-...)
Affinity DataIC50:  55nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280523(3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one | CHEMB...)
Affinity DataIC50:  59nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50006584((McN-A-343) [4-(3-Chloro-phenylcarbamoyloxy)-but-2...)
Affinity DataIC50:  64nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280529(7-Dimethylamino-hept-5-yn-2-one | CHEMBL166736)
Affinity DataIC50:  68nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280568(1-Aza-bicyclo[2.2.1]heptan-3-one O-but-3-ynyl-oxim...)
Affinity DataIC50:  83nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280569(1-Aza-bicyclo[2.2.1]heptan-3-one O-cyclobutyl-oxim...)
Affinity DataIC50:  88nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280574(1-Aza-bicyclo[2.2.1]heptan-3-one O-tert-butyl-oxim...)
Affinity DataIC50:  91nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50212580(CHEMBL170903)
Affinity DataIC50: >100nMAssay Description:Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50212575(CHEMBL165985)
Affinity DataIC50:  101nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50212581(CHEMBL167015)
Affinity DataIC50:  111nMAssay Description:Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280572(1-Aza-bicyclo[2.2.1]heptan-3-one O-propyl-oxime | ...)
Affinity DataIC50:  120nMAssay Description:Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholin...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50212577(CHEMBL168032)
Affinity DataIC50:  139nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50212578(CHEMBL167419)
Affinity DataIC50:  214nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50065224(1-Aza-bicyclo[2.2.1]heptan-3-one O-(3-methyl-but-2...)
Affinity DataIC50:  216nMAssay Description:Binding affinity of compound labeled by [3H]-QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50065209((3Z)-1-azabicyclo[2.2.1]heptan-3-oneO-[(2E)-pent-2...)
Affinity DataIC50:  216nMAssay Description:Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  360nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept...More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  364nMAssay Description:Displacement of [3H]-QNB in genetically transformed mouse cell line (m1C2) transfected with Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50212576(CHEMBL167689)
Affinity DataIC50:  373nMAssay Description:Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50280565(5-(1-Aza-bicyclo[2.2.1]hept-3-yl)-[1,2,4]oxadiazol...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]-quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cell...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  407nMAssay Description:Inhibition of 0.03 nM [3H]quinuclidinyl benzylate binding to rat neocortex muscarinic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50065224(1-Aza-bicyclo[2.2.1]heptan-3-one O-(3-methyl-but-2...)
Affinity DataIC50:  519nMAssay Description:Binding affinity of compound labeled by [3H]-QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50065209((3Z)-1-azabicyclo[2.2.1]heptan-3-oneO-[(2E)-pent-2...)
Affinity DataIC50:  519nMAssay Description:Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  858nMAssay Description:Displacement of [3H]-QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  860nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50280524(2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime | CHEM...)
Affinity DataIC50:  920nMAssay Description:Displacement of [3H]-QNB in genetically transformed mouse cell line (m1C2) transfected with Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails Article
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