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Found 335 with Last Name = 'saleh' and Initial = 't'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  0.0800nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581371(US11505527, Compound 4j)
Affinity DataIC50:  0.140nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581371(US11505527, Compound 4j)
Affinity DataIC50:  0.140nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50:  0.220nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  0.260nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581371(US11505527, Compound 4j)
Affinity DataIC50:  0.340nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  0.340nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
LigandPNGBDBM50070262(CHEMBL3408270 | US9718800, 9.02b)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50:  0.420nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  0.560nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50:  0.600nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581371(US11505527, Compound 4j)
Affinity DataIC50:  0.600nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50070324(CHEMBL3408252)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070327(CHEMBL3408262)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500920(CHEMBL3798914)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500917(CHEMBL3797698)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50048722(CHEMBL3319646)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119283(US8673906, 4.02 | US9718800, 4.02)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50:  2.10nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50500918(CHEMBL3799511)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500922(CHEMBL3797812)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070210(CHEMBL3408267)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048713(CHEMBL3319490)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070262(CHEMBL3408270 | US9718800, 9.02b)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070327(CHEMBL3408262)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500924(CHEMBL3799158)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070324(CHEMBL3408252)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500917(CHEMBL3797698)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50048713(CHEMBL3319490)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070323(CHEMBL3408250 | US9718800, 3.04b)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070325(CHEMBL3408256)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500929(CHEMBL3800231)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500922(CHEMBL3797812)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500920(CHEMBL3798914)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500925(CHEMBL3799673)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070318(CHEMBL3408277 | US9718800, 7.0b)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070326(CHEMBL3408257 | US9718800, 3.13b)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070210(CHEMBL3408267)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500915(CHEMBL3797750)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070321(CHEMBL3408247 | US9718800, 3.03b)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500917(CHEMBL3797698)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500918(CHEMBL3799511)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50500920(CHEMBL3798914)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070301(CHEMBL3408273)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50500922(CHEMBL3797812)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50070320(CHEMBL3408278 | US9718800, 7.01b)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM119292(US8673906, 4.11 | US9718800, 4.11)
Affinity DataIC50:  7nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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