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Found 5 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform' and Ligand = 'BDBM50070301'
LigandPNGBDBM50070301(CHEMBL3408273)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070301(CHEMBL3408273)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070301(CHEMBL3408273)
Affinity DataIC50:  10nMAssay Description:Tight binding affinity to human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 8...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070301(CHEMBL3408273)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070301(CHEMBL3408273)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed