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Found 179 with Last Name = 'sasaki' and Initial = 'a'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125999((R)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataKi:  0.00205nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126000((R)-2-[(S)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataKi:  0.0216nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126003((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataKi:  0.0350nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125997((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataKi:  0.0618nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125996((R)-2-[(S)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataKi:  0.0623nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125998((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataKi:  0.172nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125999((R)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataKi:  1.10nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126001((R)-2-((S)-2-Amino-3-phenyl-propionylamino)-5-guan...)
Affinity DataKi:  7.20nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126002((R)-2-[(R)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataKi:  7.60nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125998((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataKi:  482nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126003((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataKi:  544nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126000((R)-2-[(S)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataKi:  1.69E+3nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125996((R)-2-[(S)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataKi:  2.57E+3nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126002((R)-2-[(R)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataKi: >2.82E+3nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125997((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataKi: >2.82E+3nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126001((R)-2-((S)-2-Amino-3-phenyl-propionylamino)-5-guan...)
Affinity DataKi: >2.82E+3nMAssay Description:Ability of the compound to displace [3H]-deltorphin II from delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125999((R)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataIC50:  0.0340nMAssay Description:Ability of the compound to inhibit electrically induced contractions of guinea pig ileum having mu opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM9410(N-[2-(1-benzylpiperidin-4-yl)ethyl]-N-ethyl-4-(phe...)
Affinity DataIC50:  0.300nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125999((R)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataIC50:  0.398nMAssay Description:Ability of the compound to inhibit electrically induced contractions of mouse vas deferens having delta opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM9409(CHEMBL299708 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50:  0.560nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM9409(CHEMBL299708 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50:  0.600nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM9411(CHEMBL54058 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Affinity DataIC50:  0.600nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  0.690nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004016(CHEMBL138107 | CHEMBL544159 | N-(2-(2-(1-benzylpip...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126003((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataIC50:  1.70nMAssay Description:Ability of the compound to inhibit electrically induced contractions of guinea pig ileum having mu opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004007(2-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-1,3-dioxo-2,...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004001(5-Benzoyl-2-[2-(1-benzyl-piperidin-4-yl)-ethyl]-is...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126000((R)-2-[(S)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataIC50:  2.80nMAssay Description:Ability of the compound to inhibit electrically induced contractions of guinea pig ileum having mu opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004035(CHEMBL433678 | N-(2-(2-(1-benzylpiperidin-4-yl)eth...)
Affinity DataIC50:  2.80nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004018(3-(2-(1-benzylpiperidin-4-yl)ethyl)quinazoline-2,4...)
Affinity DataIC50:  4.20nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50003999(3-(2-(1-benzylpiperidin-4-yl)ethyl)-7-chloroquinaz...)
Affinity DataIC50:  4.5nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125998((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataIC50:  5.30nMAssay Description:Ability of the compound to inhibit electrically induced contractions of guinea pig ileum having mu opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50003996(CHEMBL126354 | N-(2-(1-benzylpiperidin-4-yl)ethyl)...)
Affinity DataIC50:  5.40nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004011(2-(2-(1-benzylpiperidin-4-yl)ethyl)-5-methoxyisoin...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Eisai

Curated by ChEMBL
LigandPNGBDBM50004000((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)
Affinity DataIC50:  8.10nMAssay Description:In vitro inhibitory concentration of the compound against butyrylcholinesterase (BuChE) obtained from rat plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50003998(5-Amino-2-[2-(1-benzyl-piperidin-4-yl)-ethyl]-isoi...)
Affinity DataIC50:  8.80nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004009(2-(2-(1-benzylpiperidin-4-yl)ethyl)-4-nitroisoindo...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125996((R)-2-[(S)-2-Amino-3-(2,6-dimethyl-phenyl)-propion...)
Affinity DataIC50:  9.90nMAssay Description:Ability of the compound to inhibit electrically induced contractions of guinea pig ileum having mu opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50326129(Indometacin)
Affinity DataIC50:  10nMAssay Description:Inhibition of ovine COX1 by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004015(4-Amino-2-[2-(1-benzyl-piperidin-4-yl)-ethyl]-isoi...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004033(3-(2-(1-benzylpiperidin-4-yl)ethyl)-3,4-dihydroqui...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004040(2-(2-(1-benzylpiperidin-4-yl)ethyl)-5-nitroisoindo...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004013(6-(2-(1-benzylpiperidin-4-yl)ethyl)-5H-pyrrolo[3,4...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004026(2-(2-(1-benzylpiperidin-4-yl)ethyl)-1,2-dihydroiso...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004037(CHEMBL140737 | N-(2-(1-benzylpiperidin-4-yl)ethyl)...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125997((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataIC50:  20nMAssay Description:Ability of the compound to inhibit electrically induced contractions of guinea pig ileum having mu opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004012(2-(2-(1-benzylpiperidin-4-yl)ethyl)isoquinoline-1,...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50126003((R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyla...)
Affinity DataIC50:  28nMAssay Description:Ability of the compound to inhibit electrically induced contractions of mouse vas deferens having delta opioid receptors tested in vitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM9397(CHEMBL59583 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Affinity DataIC50:  29nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Tsukuba Research Laboratories

LigandPNGBDBM50004020(2-(2-(1-benzylpiperidin-4-yl)ethyl)isoindoline-1,3...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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