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Compile Data Set for Download or QSAR

Found 18 hits Enz. Inhib. hit(s) with all data for entry = 50045333   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Androgen Receptor


(Homo sapiens (human))
BDBM50057651
PNG
(CHEMBL3326454)
Show SMILES CO[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H16ClN3O2/c1-8-10(4-3-9(7-17)12(8)16)13-15(21-2)14-11(20)5-6-19(14)18-13/h3-4,11,14-15,20H,5-6H2,1-2H3/t11-,14-,15+/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]DHT from androgen receptor in human MDA-MB-435 cells after 30 mins


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50057651
PNG
(CHEMBL3326454)
Show SMILES CO[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H16ClN3O2/c1-8-10(4-3-9(7-17)12(8)16)13-15(21-2)14-11(20)5-6-19(14)18-13/h3-4,11,14-15,20H,5-6H2,1-2H3/t11-,14-,15+/m0/s1
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n/an/a 700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Binding affinity to progesterone receptor (unknown origin) incubated for 4 hrs


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50057651
PNG
(CHEMBL3326454)
Show SMILES CO[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H16ClN3O2/c1-8-10(4-3-9(7-17)12(8)16)13-15(21-2)14-11(20)5-6-19(14)18-13/h3-4,11,14-15,20H,5-6H2,1-2H3/t11-,14-,15+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Binding affinity to glucocorticoid receptor (unknown origin) incubated for 4 hrs


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50057651
PNG
(CHEMBL3326454)
Show SMILES CO[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H16ClN3O2/c1-8-10(4-3-9(7-17)12(8)16)13-15(21-2)14-11(20)5-6-19(14)18-13/h3-4,11,14-15,20H,5-6H2,1-2H3/t11-,14-,15+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Binding affinity to estrogen receptor (unknown origin) incubated for 4 hrs


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057645
PNG
(CHEMBL3326460)
Show SMILES CO[C@H]1[C@@H]2[C@@H](F)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H15ClFN3O/c1-8-10(4-3-9(7-18)12(8)16)13-15(21-2)14-11(17)5-6-20(14)19-13/h3-4,11,14-15H,5-6H2,1-2H3/t11-,14-,15+/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057646
PNG
(CHEMBL3326459)
Show SMILES CO[C@H]1CCN2N=C([C@@H](OC)[C@H]12)c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C16H18ClN3O2/c1-9-11(5-4-10(8-18)13(9)17)14-16(22-3)15-12(21-2)6-7-20(15)19-14/h4-5,12,15-16H,6-7H2,1-3H3/t12-,15-,16+/m0/s1
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n/an/an/an/a 7.10n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057647
PNG
(CHEMBL3326458)
Show SMILES CO[C@H]1[C@@H]2[C@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H16ClN3O2/c1-8-10(4-3-9(7-17)12(8)16)13-15(21-2)14-11(20)5-6-19(14)18-13/h3-4,11,14-15,20H,5-6H2,1-2H3/t11-,14+,15-/m1/s1
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n/an/an/an/a 0.400n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057648
PNG
(CHEMBL3326457)
Show SMILES COCCO[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C17H20ClN3O3/c1-10-12(4-3-11(9-19)14(10)18)15-17(24-8-7-23-2)16-13(22)5-6-21(16)20-15/h3-4,13,16-17,22H,5-8H2,1-2H3/t13-,16-,17+/m0/s1
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n/an/an/an/a 0.930n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057649
PNG
(CHEMBL3326456)
Show SMILES CC(C)O[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C17H20ClN3O2/c1-9(2)23-17-15(20-21-7-6-13(22)16(17)21)12-5-4-11(8-19)14(18)10(12)3/h4-5,9,13,16-17,22H,6-7H2,1-3H3/t13-,16-,17+/m0/s1
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n/an/an/an/a 4.5n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057650
PNG
(CHEMBL3326455)
Show SMILES CCO[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C16H18ClN3O2/c1-3-22-16-14(19-20-7-6-12(21)15(16)20)11-5-4-10(8-18)13(17)9(11)2/h4-5,12,15-16,21H,3,6-7H2,1-2H3/t12-,15-,16+/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057651
PNG
(CHEMBL3326454)
Show SMILES CO[C@H]1[C@@H]2[C@@H](O)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H16ClN3O2/c1-8-10(4-3-9(7-17)12(8)16)13-15(21-2)14-11(20)5-6-19(14)18-13/h3-4,11,14-15,20H,5-6H2,1-2H3/t11-,14-,15+/m0/s1
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n/an/an/an/a 0.5n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Androgen Receptor


(Homo sapiens (human))
BDBM50057652
PNG
(CHEMBL3326453)
Show SMILES Cc1c(Cl)c(ccc1C1=NN2CC[C@H](O)[C@H]2[C@@H]1O)C#N
Show InChI InChI=1S/C14H14ClN3O2/c1-7-9(3-2-8(6-16)11(7)15)12-14(20)13-10(19)4-5-18(13)17-12/h2-3,10,13-14,19-20H,4-5H2,1H3/t10-,13-,14+/m0/s1
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n/an/an/an/a 978n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50410541
PNG
(CHEMBL194467)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@H]2O
Show InChI InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17+,18-,19-/m0/s1
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n/an/an/an/a 0.130n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057644
PNG
(CHEMBL3326461)
Show SMILES CO[C@H]1[C@@H]2[C@H](F)CCN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H15ClFN3O/c1-8-10(4-3-9(7-18)12(8)16)13-15(21-2)14-11(17)5-6-20(14)19-13/h3-4,11,14-15H,5-6H2,1-2H3/t11-,14+,15-/m1/s1
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n/an/an/an/a 0.160n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057643
PNG
(CHEMBL3326462)
Show SMILES CO[C@H]1[C@@H]2C[C@@H](O)CN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H16ClN3O2/c1-8-11(4-3-9(6-17)13(8)16)14-15(21-2)12-5-10(20)7-19(12)18-14/h3-4,10,12,15,20H,5,7H2,1-2H3/t10-,12+,15+/m1/s1
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n/an/an/an/a 9.70n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057642
PNG
(CHEMBL3326464)
Show SMILES CO[C@H]1[C@@H]2C[C@H](F)CN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H15ClFN3O/c1-8-11(4-3-9(6-18)13(8)16)14-15(21-2)12-5-10(17)7-20(12)19-14/h3-4,10,12,15H,5,7H2,1-2H3/t10-,12-,15-/m0/s1
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n/an/an/an/a 1.40n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057640
PNG
(CHEMBL3326466)
Show SMILES CO[C@H]1[C@@H]2CC(F)(F)CN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H14ClF2N3O/c1-8-10(4-3-9(6-19)12(8)16)13-14(22-2)11-5-15(17,18)7-21(11)20-13/h3-4,11,14H,5,7H2,1-2H3/t11-,14-/m0/s1
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n/an/an/an/a 0.300n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50057641
PNG
(CHEMBL3326465)
Show SMILES CO[C@H]1[C@@H]2CC(=O)CN2N=C1c1ccc(C#N)c(Cl)c1C
Show InChI InChI=1S/C15H14ClN3O2/c1-8-11(4-3-9(6-17)13(8)16)14-15(21-2)12-5-10(20)7-19(12)18-14/h3-4,12,15H,5,7H2,1-2H3/t12-,15-/m0/s1
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n/an/an/an/a 26n/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assa...


J Med Chem 57: 7396-411 (2014)


Article DOI: 10.1021/jm5009049
BindingDB Entry DOI: 10.7270/Q2RB768M
More data for this
Ligand-Target Pair