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Compile Data Set for Download or QSAR

Found 25 hits Enz. Inhib. hit(s) with all data for entry = 50048022   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Biotin--protein ligase


(Homo sapiens)
BDBM50201186
PNG
(CHEMBL3923732)
Show SMILES COc1ccccc1Cn1cc(CCCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1
Show InChI InChI=1S/C20H27N5O2S/c1-27-17-9-6-5-7-14(17)11-25-12-15(23-24-25)8-3-2-4-10-18-19-16(13-28-18)21-20(26)22-19/h5-7,9,12,16,18-19H,2-4,8,10-11,13H2,1H3,(H2,21,22,26)/t16-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201210
PNG
(CHEMBL3933745)
Show SMILES Nc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C19H26N6OS/c20-14-8-6-13(7-9-14)10-25-11-15(23-24-25)4-2-1-3-5-17-18-16(12-27-17)21-19(26)22-18/h6-9,11,16-18H,1-5,10,12,20H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201188
PNG
(CHEMBL3891635)
Show SMILES Cc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C20H27N5OS/c1-14-7-9-15(10-8-14)11-25-12-16(23-24-25)5-3-2-4-6-18-19-17(13-27-18)21-20(26)22-19/h7-10,12,17-19H,2-6,11,13H2,1H3,(H2,21,22,26)/t17-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201189
PNG
(CHEMBL3984675)
Show SMILES Clc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C19H24ClN5OS/c20-14-8-6-13(7-9-14)10-25-11-15(23-24-25)4-2-1-3-5-17-18-16(12-27-17)21-19(26)22-18/h6-9,11,16-18H,1-5,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201190
PNG
(CHEMBL3942705)
Show SMILES Nc1ccccc1Cn1cc(CCCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1
Show InChI InChI=1S/C19H26N6OS/c20-15-8-5-4-6-13(15)10-25-11-14(23-24-25)7-2-1-3-9-17-18-16(12-27-17)21-19(26)22-18/h4-6,8,11,16-18H,1-3,7,9-10,12,20H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201191
PNG
(CHEMBL3951442)
Show SMILES COc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C20H27N5O2S/c1-27-16-8-5-6-14(10-16)11-25-12-15(23-24-25)7-3-2-4-9-18-19-17(13-28-18)21-20(26)22-19/h5-6,8,10,12,17-19H,2-4,7,9,11,13H2,1H3,(H2,21,22,26)/t17-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201192
PNG
(CHEMBL3932681)
Show SMILES Oc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C19H25N5O2S/c25-15-7-4-5-13(9-15)10-24-11-14(22-23-24)6-2-1-3-8-17-18-16(12-27-17)20-19(26)21-18/h4-5,7,9,11,16-18,25H,1-3,6,8,10,12H2,(H2,20,21,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201193
PNG
(CHEMBL3974372)
Show SMILES Cc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C20H27N5OS/c1-14-6-5-7-15(10-14)11-25-12-16(23-24-25)8-3-2-4-9-18-19-17(13-27-18)21-20(26)22-19/h5-7,10,12,17-19H,2-4,8-9,11,13H2,1H3,(H2,21,22,26)/t17-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201194
PNG
(CHEMBL3932600)
Show SMILES FC(F)(F)c1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C20H24F3N5OS/c21-20(22,23)14-8-6-13(7-9-14)10-28-11-15(26-27-28)4-2-1-3-5-17-18-16(12-30-17)24-19(29)25-18/h6-9,11,16-18H,1-5,10,12H2,(H2,24,25,29)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201195
PNG
(CHEMBL3972792)
Show SMILES OC(=O)c1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C20H25N5O3S/c26-19(27)14-8-6-13(7-9-14)10-25-11-15(23-24-25)4-2-1-3-5-17-18-16(12-29-17)21-20(28)22-18/h6-9,11,16-18H,1-5,10,12H2,(H,26,27)(H2,21,22,28)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201196
PNG
(CHEMBL3961751)
Show SMILES Ic1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C19H24IN5OS/c20-14-6-4-5-13(9-14)10-25-11-15(23-24-25)7-2-1-3-8-17-18-16(12-27-17)21-19(26)22-18/h4-6,9,11,16-18H,1-3,7-8,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201197
PNG
(CHEMBL3895686)
Show SMILES Ic1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C19H24IN5OS/c20-14-8-6-13(7-9-14)10-25-11-15(23-24-25)4-2-1-3-5-17-18-16(12-27-17)21-19(26)22-18/h6-9,11,16-18H,1-5,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201198
PNG
(CHEMBL3968104)
Show SMILES Fc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C19H24FN5OS/c20-14-6-4-5-13(9-14)10-25-11-15(23-24-25)7-2-1-3-8-17-18-16(12-27-17)21-19(26)22-18/h4-6,9,11,16-18H,1-3,7-8,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201199
PNG
(CHEMBL3934430)
Show SMILES Fc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C19H24FN5OS/c20-14-8-6-13(7-9-14)10-25-11-15(23-24-25)4-2-1-3-5-17-18-16(12-27-17)21-19(26)22-18/h6-9,11,16-18H,1-5,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201200
PNG
(CHEMBL3905875)
Show SMILES Clc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C19H24ClN5OS/c20-14-6-4-5-13(9-14)10-25-11-15(23-24-25)7-2-1-3-8-17-18-16(12-27-17)21-19(26)22-18/h4-6,9,11,16-18H,1-3,7-8,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201201
PNG
(CHEMBL3901708)
Show SMILES CC(C)(C)c1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C23H33N5OS/c1-23(2,3)17-11-9-16(10-12-17)13-28-14-18(26-27-28)7-5-4-6-8-20-21-19(15-30-20)24-22(29)25-21/h9-12,14,19-21H,4-8,13,15H2,1-3H3,(H2,24,25,29)/t19-,20-,21-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201202
PNG
(CHEMBL3971239)
Show SMILES Oc1ccccc1Cn1cc(CCCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1
Show InChI InChI=1S/C19H25N5O2S/c25-16-8-5-4-6-13(16)10-24-11-14(22-23-24)7-2-1-3-9-17-18-15(12-27-17)20-19(26)21-18/h4-6,8,11,15,17-18,25H,1-3,7,9-10,12H2,(H2,20,21,26)/t15-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201203
PNG
(CHEMBL3905724)
Show SMILES Nc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C19H26N6OS/c20-14-6-4-5-13(9-14)10-25-11-15(23-24-25)7-2-1-3-8-17-18-16(12-27-17)21-19(26)22-18/h4-6,9,11,16-18H,1-3,7-8,10,12,20H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201204
PNG
(CHEMBL3927537)
Show SMILES Fc1ccccc1Cn1cc(CCCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1
Show InChI InChI=1S/C19H24FN5OS/c20-15-8-5-4-6-13(15)10-25-11-14(23-24-25)7-2-1-3-9-17-18-16(12-27-17)21-19(26)22-18/h4-6,8,11,16-18H,1-3,7,9-10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201205
PNG
(CHEMBL3914706)
Show SMILES COc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C20H27N5O2S/c1-27-16-9-7-14(8-10-16)11-25-12-15(23-24-25)5-3-2-4-6-18-19-17(13-28-18)21-20(26)22-19/h7-10,12,17-19H,2-6,11,13H2,1H3,(H2,21,22,26)/t17-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201206
PNG
(CHEMBL3960176)
Show SMILES Oc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C19H25N5O2S/c25-15-8-6-13(7-9-15)10-24-11-14(22-23-24)4-2-1-3-5-17-18-16(12-27-17)20-19(26)21-18/h6-9,11,16-18,25H,1-5,10,12H2,(H2,20,21,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201207
PNG
(CHEMBL3910734)
Show SMILES FC(F)(F)c1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C20H24F3N5OS/c21-20(22,23)14-6-4-5-13(9-14)10-28-11-15(26-27-28)7-2-1-3-8-17-18-16(12-30-17)24-19(29)25-18/h4-6,9,11,16-18H,1-3,7-8,10,12H2,(H2,24,25,29)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201208
PNG
(CHEMBL3892750)
Show SMILES Brc1ccccc1Cn1cc(CCCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1
Show InChI InChI=1S/C19H24BrN5OS/c20-15-8-5-4-6-13(15)10-25-11-14(23-24-25)7-2-1-3-9-17-18-16(12-27-17)21-19(26)22-18/h4-6,8,11,16-18H,1-3,7,9-10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201209
PNG
(CHEMBL3914868)
Show SMILES Fc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1F
Show InChI InChI=1S/C19H23F2N5OS/c20-14-7-6-12(8-15(14)21)9-26-10-13(24-25-26)4-2-1-3-5-17-18-16(11-28-17)22-19(27)23-18/h6-8,10,16-18H,1-5,9,11H2,(H2,22,23,27)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens)
BDBM50201187
PNG
(CHEMBL3976601)
Show SMILES Clc1ccccc1Cn1cc(CCCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1
Show InChI InChI=1S/C19H24ClN5OS/c20-15-8-5-4-6-13(15)10-25-11-14(23-24-25)7-2-1-3-9-17-18-16(12-27-17)21-19(26)22-18/h4-6,8,11,16-18H,1-3,7,9-10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair