Affinity DataIC50: 100nMAssay Description:Inhibitory activity of the compound against human platelet 12-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Compound was tested in vitro for inhibition of 12-LO human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:In vitro 5-lipoxygenase inhibitory activity of the compound against calcium ionophore (A23187) induced LTB4 formation in human whole bloodMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Compound was tested in vitro for inhibition of 15-lipoxygenase soyabeanMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibitory activity of the compound against soyabean 15-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of 5-Lipoxygenase of rat basophilic leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:In vitro 5-lipoxygenase inhibitory activity of the compound against calcium ionophore (A23187) induced LTB4 formation in rat polymorphonuclear leukoc...More data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:In vitro inhibition of rat 5-LipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 570nMAssay Description:Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human polymorphonuclear leukocytes.More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:In vitro inhibition of 5-lipoxygenase activity in RBL-1 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase.More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:In vitro inhibitory activity against RBL-1 5-LOMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells.More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:In vitro inhibition of RBL-1 5-lipoxygenase; Value ranges from 1.07-5.54More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against 15-lipoxygenase was determined obtained from soya beanMore data for this Ligand-Target Pair
Affinity DataIC50: 2.54E+3nMAssay Description:In vitro inhibitory concentration against 5-lipoxygenase in RBL-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of PGE-2 production was measured in rat bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of rat basophilic leukemia-1 (RBL-1) 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Compound was evaluated for inhibition against cyclooxygenase of bovine seminal vesiclesMore data for this Ligand-Target Pair
Affinity DataIC50: 9.20E+3nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of LTB4 production was measured in rat bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against human whole blood, TXB2 cyclooxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Compound was evaluated for inhibition against Phospholipase A2 of Croatalus adamanteusMore data for this Ligand-Target Pair