Found 80 of ic50 for monomerid = 50070942 Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase(Plasmodium falciparum)
University Of Bologna
Curated by ChEMBL
University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant Plasmodium falciparum FabZ using crotonoyl-CoA as substrate after 10 minsMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Institute Of Agricultural And Food Biotechnology
Curated by ChEMBL
Institute Of Agricultural And Food Biotechnology
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of chymotrypsin-like activity of purified human 20S proteasome assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 91nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:Inhibition of Bacillus anthracis lethal factorMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The Hong Kong Polytechnic University
Curated by ChEMBL
The Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 123nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa...More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
The Hong Kong Polytechnic University
Curated by ChEMBL
The Hong Kong Polytechnic University
Curated by ChEMBL
Affinity DataIC50: 124nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa...More data for this Ligand-Target Pair
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
University Of Zurich
Curated by ChEMBL
University Of Zurich
Curated by ChEMBL
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Avanti Biosciences
Curated by ChEMBL
Avanti Biosciences
Curated by ChEMBL
Affinity DataIC50: 232nMAssay Description:Inhibition of DYRK1A (unknown origin) using HT-497 as substrate preincubated with compound followed by substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
University Of Zurich
Curated by ChEMBL
University Of Zurich
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of Plasmodium falciparum ENRMore data for this Ligand-Target Pair
TargetGlucose-6-phosphate 1-dehydrogenase(Saccharomyces cerevisiae S288c)
Amorepacific
Curated by ChEMBL
Amorepacific
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of yeast G6PDMore data for this Ligand-Target Pair
TargetDNA repair protein RAD52 homolog(Homo sapiens)
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Affinity DataIC50: 277nMAssay Description:Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
Target3-oxoacyl-acyl-carrier protein reductase(Plasmodium falciparum)
University Of Zurich
Curated by ChEMBL
University Of Zurich
Curated by ChEMBL
Target3-oxoacyl-[acyl-carrier-protein] reductase(Plasmodium falciparum (isolate 3D7))
University Of Bologna
Curated by ChEMBL
University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant Plasmodium falciparum 3D7 FabG using acetoacetyl-CoA as substrate after 10 mins in presence of NADPHMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Avanti Biosciences
Curated by ChEMBL
Avanti Biosciences
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Avanti Biosciences
Curated by ChEMBL
Avanti Biosciences
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 40 mins in presence of [gamma...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Avanti Biosciences
Curated by ChEMBL
Avanti Biosciences
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of human GST-fused DYRK1A expressed in Escherichia coli using KISGRLSPIMTEQ as substrateMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
India Academy Of Scientific & Innovative Research (Acsir)
Curated by ChEMBL
India Academy Of Scientific & Innovative Research (Acsir)
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of rat Dyrk1A using Woodtide as substrate after 40 mins by P81 membrane assay in presence of [33P]-g-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase(Plasmodium falciparum)
University Of Bologna
Curated by ChEMBL
University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant human His-tagged PGAM1 expressed in Escherichia coli BL21 competent cells by kinase-glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant His-tagged PGAM1 (unknown origin) expressed in Escherichia coli BL21 using 3-PG as substrate in presence of ADP by Kinase-G...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation incubated at 37 degC for 16 hrs by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biot...More data for this Ligand-Target Pair
Affinity DataIC50: 580nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Inhibition of rat squalene epoxidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant rat SE(squalene epoxidase)More data for this Ligand-Target Pair
Affinity DataIC50: 700nMpH: 7.3 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
Target6-phosphogluconate dehydrogenase, decarboxylating(Homo sapiens (Human))
Amorepacific
Curated by ChEMBL
Amorepacific
Curated by ChEMBL
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
University Of Toledo
Curated by ChEMBL
University Of Toledo
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTPMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute Of Pharmacology And Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology And Toxicology
Curated by ChEMBL
Affinity DataIC50: 757nMAssay Description:Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 960nMAssay Description:Inhibition of NADK delta 95 kinase domain (unknown origin) at 80 uM measured after 30 mins by HDX-MS analysisMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Institute Of Agricultural And Food Biotechnology
Curated by ChEMBL
Institute Of Agricultural And Food Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of chymotrypsin-like activity of human 26S proteasome extracted from human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly...More data for this Ligand-Target Pair
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of telomerase in human U937 cellsMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRAK (unknown origin)More data for this Ligand-Target Pair
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...More data for this Ligand-Target Pair
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Beijing Institute Of Pharmacology And Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology And Toxicology
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of BACE1 using Rh-EVNLDAEFK-Quencher as substrateMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan
Curated by ChEMBL
Abdul Wali Khan University Mardan
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6(Homo sapiens (Human))
Schering-Plough Research Institute
Schering-Plough Research Institute
Affinity DataIC50: 1.80E+3nMpH: 7.3 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Humboldt Universit£T Zu Berlin
Curated by ChEMBL
Humboldt Universit£T Zu Berlin
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant brain tau protein (412 amino acid residues) filament assembly expressed in Escherichia coli BL21(DE3) by electron mic...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMpH: 7.3 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University Of Freiburg
Curated by ChEMBL
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of p38alpha after 1 hr by ELISAMore data for this Ligand-Target Pair
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMpH: 7.5 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of amyloid beta1-42 (unknown origin) aggregation assessed as amyloid fibril formation tested after 17 hrs by thioflavin T fluorescence met...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
Yonsei University
Curated by ChEMBL
Yonsei University
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Escherichia coli FabI using trans-2-octanoyl-N-acetylcysteamine as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetPolymerase acidic protein(Hepatitis C virus)
South China Agricultural University
Curated by ChEMBL
South China Agricultural University
Curated by ChEMBL
Affinity DataIC50: 5.86E+3nMAssay Description:Inhibition of Influenza A virus N-terminal domain of PA endonuclease using 6FAM-TGGCAATATCAGCTCCACA-MGBNFQ as fluorescent substrate by FRET analysisMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
University Of Shizuoka And Global Coe Program
Curated by ChEMBL
University Of Shizuoka And Global Coe Program
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human recombinant MT1-MMP expressed in Escherichia coli by fluorogenic peptide cleavage assayMore data for this Ligand-Target Pair
TargetThiosulfate sulfurtransferase(Homo sapiens)
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+3nMpH: 7.5 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
