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Compile Data Set for Download or QSAR

Found 72 hits of ec50 for UniProtKB: P33533   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221788
PNG
(CHEMBL2369900)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O
Show InChI InChI=1S/C30H42N6O6S/c1-18(2)26(36-28(40)22(31)15-20-9-11-21(37)12-10-20)30(42)33-17-25(38)34-24(16-19-7-5-4-6-8-19)29(41)35-23(27(32)39)13-14-43-3/h4-12,18,22-24,26,37H,13-17,31H2,1-3H3,(H2,32,39)(H,33,42)(H,34,38)(H,35,41)(H,36,40)/t22-,23+,24+,26-/m0/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221789
PNG
(CHEMBL14570)
Show SMILES CC(C)C[C@@H](NC(=O)[C@](C)(Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C30H41N5O7/c1-18(2)14-24(28(40)41)34-29(42)30(4,16-21-8-6-5-7-9-21)35-25(37)17-32-26(38)19(3)33-27(39)23(31)15-20-10-12-22(36)13-11-20/h5-13,18-19,23-24,36H,14-17,31H2,1-4H3,(H,32,38)(H,33,39)(H,34,42)(H,35,37)(H,40,41)/t19-,23-,24+,30-/m0/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221792
PNG
(CHEMBL14211)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)NCc1ccccc1
Show InChI InChI=1S/C21H26N4O4/c1-14(25-21(29)18(22)11-15-7-9-17(26)10-8-15)20(28)24-13-19(27)23-12-16-5-3-2-4-6-16/h2-10,14,18,26H,11-13,22H2,1H3,(H,23,27)(H,24,28)(H,25,29)/t14-,18-/m0/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50000092
PNG
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O
Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM21025
PNG
((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221797
PNG
(CHEMBL274663)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)NCCc1ccccc1
Show InChI InChI=1S/C22H28N4O4/c1-15(26-22(30)19(23)13-17-7-9-18(27)10-8-17)21(29)25-14-20(28)24-12-11-16-5-3-2-4-6-16/h2-10,15,19,27H,11-14,23H2,1H3,(H,24,28)(H,25,29)(H,26,30)/t15-,19-/m0/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221799
PNG
(CHEMBL2369922)
Show SMILES CC(C)[C@H](NC(=O)[C@](C)(Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C29H39N5O7/c1-17(2)24(27(39)40)33-28(41)29(4,15-20-8-6-5-7-9-20)34-23(36)16-31-25(37)18(3)32-26(38)22(30)14-19-10-12-21(35)13-11-19/h5-13,17-18,22,24,35H,14-16,30H2,1-4H3,(H,31,37)(H,32,38)(H,33,41)(H,34,36)(H,39,40)/t18-,22+,24+,29+/m1/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221793
PNG
(CHEMBL2369921)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)NC1CCc2ccccc12
Show InChI InChI=1S/C23H28N4O4/c1-14(26-23(31)19(24)12-15-6-9-17(28)10-7-15)22(30)25-13-21(29)27-20-11-8-16-4-2-3-5-18(16)20/h2-7,9-10,14,19-20,28H,8,11-13,24H2,1H3,(H,25,30)(H,26,31)(H,27,29)/t14-,19+,20?/m1/s1
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n/an/an/an/a 0n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221802
PNG
(CHEMBL13767)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C29H45N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h9-12,17-19,22-24,35H,4-8,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22-,23-,24-/m0/s1
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n/an/an/an/a 0.00000100n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221804
PNG
(CHEMBL13834)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C22H25N3O6/c1-14(25-21(29)18(23)11-15-7-9-17(26)10-8-15)20(28)24-12-19(27)22(30)31-13-16-5-3-2-4-6-16/h2-10,14,18,26H,11-13,23H2,1H3,(H,24,28)(H,25,29)/t14-,18-/m0/s1
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n/an/an/an/a 0.00000100n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221790
PNG
(CHEMBL274575)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)NCC1CCC1
Show InChI InChI=1S/C19H28N4O4/c1-12(18(26)22-11-17(25)21-10-14-3-2-4-14)23-19(27)16(20)9-13-5-7-15(24)8-6-13/h5-8,12,14,16,24H,2-4,9-11,20H2,1H3,(H,21,25)(H,22,26)(H,23,27)/t12-,16-/m0/s1
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n/an/an/an/a 0.00000200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221794
PNG
(CHEMBL13688)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)NCC1CC1
Show InChI InChI=1S/C18H26N4O4/c1-11(17(25)21-10-16(24)20-9-13-2-3-13)22-18(26)15(19)8-12-4-6-14(23)7-5-12/h4-7,11,13,15,23H,2-3,8-10,19H2,1H3,(H,20,24)(H,21,25)(H,22,26)/t11-,15-/m0/s1
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n/an/an/an/a 0.00000200n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221801
PNG
(CHEMBL2369909)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)NC1CCc2ccccc12
Show InChI InChI=1S/C25H32N4O4/c1-15(2)23(29-24(32)20(26)13-16-7-10-18(30)11-8-16)25(33)27-14-22(31)28-21-12-9-17-5-3-4-6-19(17)21/h3-8,10-11,15,20-21,23,30H,9,12-14,26H2,1-2H3,(H,27,33)(H,28,31)(H,29,32)/t20-,21?,23-/m0/s1
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n/an/an/an/a 0.00000500n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221800
PNG
(CHEMBL13713)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)NC1Cc2ccccc2C1
Show InChI InChI=1S/C23H28N4O4/c1-14(26-23(31)20(24)10-15-6-8-19(28)9-7-15)22(30)25-13-21(29)27-18-11-16-4-2-3-5-17(16)12-18/h2-9,14,18,20,28H,10-13,24H2,1H3,(H,25,30)(H,26,31)(H,27,29)/t14-,20-/m0/s1
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n/an/an/an/a 0.0000190n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221791
PNG
(CHEMBL273288)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)NC1CCc2ccccc12
Show InChI InChI=1S/C22H26N4O4/c23-18(11-14-5-8-16(27)9-6-14)22(30)25-12-20(28)24-13-21(29)26-19-10-7-15-3-1-2-4-17(15)19/h1-6,8-9,18-19,27H,7,10-13,23H2,(H,24,28)(H,25,30)(H,26,29)/t18-,19?/m0/s1
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n/an/an/an/a 0.0000340n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221795
PNG
(CHEMBL13665)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@](C)(N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C30H41N5O7/c1-18(2)14-24(28(40)41)35-27(39)23(15-20-8-6-5-7-9-20)34-25(37)17-32-26(38)19(3)33-29(42)30(4,31)16-21-10-12-22(36)13-11-21/h5-13,18-19,23-24,36H,14-17,31H2,1-4H3,(H,32,38)(H,33,42)(H,34,37)(H,35,39)(H,40,41)/t19-,23+,24+,30+/m0/s1
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n/an/an/an/a>0.000650n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221803
PNG
(CHEMBL274367)
Show SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C14H19N3O5/c1-8(13(21)16-7-12(19)20)17-14(22)11(15)6-9-2-4-10(18)5-3-9/h2-5,8,11,18H,6-7,15H2,1H3,(H,16,21)(H,17,22)(H,19,20)/t8-,11-/m0/s1
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n/an/an/an/a 0.000700n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50221796
PNG
(CHEMBL2369920)
Show SMILES CCOC(=O)CC[C@H](N)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C27H41N5O8/c1-5-40-23(34)12-11-19(28)25(36)30-17(4)24(35)29-15-22(33)31-20(14-18-9-7-6-8-10-18)26(37)32-21(27(38)39)13-16(2)3/h6-10,16-17,19-21H,5,11-15,28H2,1-4H3,(H,29,35)(H,30,36)(H,31,33)(H,32,37)(H,38,39)/t17-,19+,20+,21-/m1/s1
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n/an/an/an/a 0.000760n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM29135
PNG
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Show SMILES NCCc1ccc(O)cc1
Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
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n/an/an/an/a>0.00100n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl


J Med Chem 23: 1113-22 (1980)


Article DOI: 10.1021/jm00184a010
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50367061
PNG
(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Show SMILES O[C@H]1C=C[C@H]2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45
Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50000092
PNG
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O
Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185312
PNG
(CHEMBL3823787)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(C(=O)C2CCC2)c2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C32H37N3O3/c1-20-15-25(36)16-21(2)26(20)19-28(33)31(37)34-29-13-14-35(32(38)24-9-6-10-24)30-12-11-23(18-27(29)30)17-22-7-4-3-5-8-22/h3-5,7-8,11-12,15-16,18,24,28-29,36H,6,9-10,13-14,17,19,33H2,1-2H3,(H,34,37)/t28-,29+/m0/s1
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n/an/an/an/a 5.10n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50225933
PNG
(CHEMBL2310921)
Show SMILES OC(=O)C(O)=O.COC(=O)\C=C\C(=O)N[C@H]1C[C@]23C=CC1(OC)[C@@H]1Oc4c5c(C[C@H]2N(CC2CC2)CC[C@@]315)ccc4O
Show InChI InChI=1S/C28H32N2O6.C2H2O4/c1-34-22(33)8-7-21(32)29-19-14-26-9-10-28(19,35-2)25-27(26)11-12-30(15-16-3-4-16)20(26)13-17-5-6-18(31)24(36-25)23(17)27;3-1(4)2(5)6/h5-10,16,19-20,25,31H,3-4,11-15H2,1-2H3,(H,29,32);(H,3,4)(H,5,6)/b8-7+;/t19-,20+,25+,26+,27-,28?;/m0./s1
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n/an/an/an/a 6n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50225937
PNG
(CHEMBL3038189)
Show SMILES CO[C@]12C=C[C@@]3(C[C@@H]1N)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1S/C23H28N2O3/c1-27-23-7-6-21(11-16(23)24)17-10-14-4-5-15(26)19-18(14)22(21,20(23)28-19)8-9-25(17)12-13-2-3-13/h4-7,13,16-17,20,26H,2-3,8-12,24H2,1H3/t16-,17+,20+,21+,22-,23+/m0/s1
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n/an/an/an/a 6n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50225936
PNG
(CHEMBL3038190)
Show SMILES CO[C@]12C=C[C@@]3(C[C@@H]1NC(=O)CBr)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1S/C25H29BrN2O4/c1-31-25-7-6-23(11-17(25)27-19(30)12-26)18-10-15-4-5-16(29)21-20(15)24(23,22(25)32-21)8-9-28(18)13-14-2-3-14/h4-7,14,17-18,22,29H,2-3,8-13H2,1H3,(H,27,30)/t17-,18+,22+,23+,24-,25+/m0/s1
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n/an/an/an/a 7n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50225935
PNG
(CHEMBL2310915)
Show SMILES OC(=O)C(O)=O.COC12C=C[C@@]3(C[C@@H]1N=S)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1S/C23H26N2O3S.C2H2O4/c1-27-23-7-6-21(11-16(23)24-29)17-10-14-4-5-15(26)19-18(14)22(21,20(23)28-19)8-9-25(17)12-13-2-3-13;3-1(4)2(5)6/h4-7,13,16-17,20,26H,2-3,8-12H2,1H3;(H,3,4)(H,5,6)/t16-,17+,20+,21+,22-,23?;/m0./s1
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n/an/an/an/a 7n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50240354
PNG
(CHEMBL274844 | N-{1-[2-(4-Isothiocyanato-phenyl)-e...)
Show SMILES CCC(=O)N(C1CCN(CCc2ccc(cc2)N=C=S)CC1)c1ccccc1
Show InChI InChI=1S/C23H27N3OS/c1-2-23(27)26(21-6-4-3-5-7-21)22-13-16-25(17-14-22)15-12-19-8-10-20(11-9-19)24-18-28/h3-11,22H,2,12-17H2,1H3
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n/an/an/an/a 8n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity was evaluated against [3H]dalamid binding to neuroblastoma X glioma hybrid cell NG108-15 (Opioid receptor delta 1)membranes


J Med Chem 27: 1570-4 (1985)


Article DOI: 10.1021/jm00378a008
BindingDB Entry DOI: 10.7270/Q2S18328
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185309
PNG
(CHEMBL3824052)
Show SMILES CCCC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12
Show InChI InChI=1S/C31H37N3O3/c1-4-8-30(36)34-14-13-28(26-18-23(11-12-29(26)34)17-22-9-6-5-7-10-22)33-31(37)27(32)19-25-20(2)15-24(35)16-21(25)3/h5-7,9-12,15-16,18,27-28,35H,4,8,13-14,17,19,32H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
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n/an/an/an/a 8.10n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185311
PNG
(CHEMBL3823231)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCN(C(=O)C2CC2)c2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C31H35N3O3/c1-19-14-24(35)15-20(2)25(19)18-27(32)30(36)33-28-12-13-34(31(37)23-9-10-23)29-11-8-22(17-26(28)29)16-21-6-4-3-5-7-21/h3-8,11,14-15,17,23,27-28,35H,9-10,12-13,16,18,32H2,1-2H3,(H,33,36)/t27-,28+/m0/s1
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n/an/an/an/a 10n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185313
PNG
(CHEMBL3823830)
Show SMILES COC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12
Show InChI InChI=1S/C29H33N3O4/c1-18-13-22(33)14-19(2)23(18)17-25(30)28(34)31-26-11-12-32(29(35)36-3)27-10-9-21(16-24(26)27)15-20-7-5-4-6-8-20/h4-10,13-14,16,25-26,33H,11-12,15,17,30H2,1-3H3,(H,31,34)/t25-,26+/m0/s1
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n/an/an/an/a 14n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50133885
PNG
(CHEMBL3634250)
Show SMILES CC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(CC3CCCCC3)ccc12
Show InChI InChI=1S/C29H39N3O3/c1-18-13-23(34)14-19(2)24(18)17-26(30)29(35)31-27-11-12-32(20(3)33)28-10-9-22(16-25(27)28)15-21-7-5-4-6-8-21/h9-10,13-14,16,21,26-27,34H,4-8,11-12,15,17,30H2,1-3H3,(H,31,35)/t26-,27+/m0/s1
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n/an/an/an/a 14n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat delta-opioid receptor expressed in C6 cell membrane assessed as [35S]GTPgammaS binding for 1 hr by liquid scintillation count...


J Med Chem 58: 8952-69 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01270
BindingDB Entry DOI: 10.7270/Q2RR213J
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185317
PNG
(CHEMBL3823815)
Show SMILES CCOC(=O)CN1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12
Show InChI InChI=1S/C31H37N3O4/c1-4-38-30(36)19-34-13-12-28(26-17-23(10-11-29(26)34)16-22-8-6-5-7-9-22)33-31(37)27(32)18-25-20(2)14-24(35)15-21(25)3/h5-11,14-15,17,27-28,35H,4,12-13,16,18-19,32H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
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n/an/an/an/a 15n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50027091
PNG
(19-isothiocyanato-15-methoxy-3-methyl-13-oxa-3-aza...)
Show SMILES CO[C@]12C=C[C@@]3(C[C@@H]1N=C=S)C1Cc4ccc(O)c5O[C@@H]2C3(CCN1C)c45
Show InChI InChI=1S/C21H22N2O3S/c1-23-8-7-20-16-12-3-4-13(24)17(16)26-18(20)21(25-2)6-5-19(20,15(23)9-12)10-14(21)22-11-27/h3-6,14-15,18,24H,7-10H2,1-2H3/t14-,15?,18+,19+,20?,21+/m0/s1
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n/an/an/an/a 20n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity was evaluated against [3H]dalamid binding to neuroblastoma X glioma hybrid cell NG108-15 (Opioid receptor delta 1)membranes


J Med Chem 27: 1570-4 (1985)


Article DOI: 10.1021/jm00378a008
BindingDB Entry DOI: 10.7270/Q2S18328
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50142699
PNG
(CHEMBL3759831)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](CSSC[C@@H](NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C34H41N5O7S2/c1-2-3-11-26-31(42)39-29(34(45)46)19-48-47-18-28(38-30(41)25(35)16-20-12-14-23(40)15-13-20)33(44)37-27(32(43)36-26)17-22-9-6-8-21-7-4-5-10-24(21)22/h4-10,12-15,25-29,40H,2-3,11,16-19,35H2,1H3,(H,36,43)(H,37,44)(H,38,41)(H,39,42)(H,45,46)/t25-,26-,27-,28-,29+/m0/s1
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n/an/an/an/a 22n/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Agonist activity at rat delta opioid receptor transfected in C6 cells by [35S]GTPgammaS binding assay


Eur J Med Chem 108: 211-28 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.028
BindingDB Entry DOI: 10.7270/Q2R2137W
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50142697
PNG
(CHEMBL3759294)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](CSSC[C@@H](NC1=O)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C34H42N6O6S2/c1-2-3-11-26-32(44)39-28(30(36)42)18-47-48-19-29(40-31(43)25(35)16-20-12-14-23(41)15-13-20)34(46)38-27(33(45)37-26)17-22-9-6-8-21-7-4-5-10-24(21)22/h4-10,12-15,25-29,41H,2-3,11,16-19,35H2,1H3,(H2,36,42)(H,37,45)(H,38,46)(H,39,44)(H,40,43)/t25-,26-,27-,28+,29-/m0/s1
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n/an/an/an/a 22n/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Agonist activity at rat delta opioid receptor transfected in C6 cells by [35S]GTPgammaS binding assay


Eur J Med Chem 108: 211-28 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.028
BindingDB Entry DOI: 10.7270/Q2R2137W
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185310
PNG
(CHEMBL3824042)
Show SMILES CC(C)C(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12
Show InChI InChI=1S/C31H37N3O3/c1-19(2)31(37)34-13-12-28(26-17-23(10-11-29(26)34)16-22-8-6-5-7-9-22)33-30(36)27(32)18-25-20(3)14-24(35)15-21(25)4/h5-11,14-15,17,19,27-28,35H,12-13,16,18,32H2,1-4H3,(H,33,36)/t27-,28+/m0/s1
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n/an/an/an/a 25n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185308
PNG
(CHEMBL3822956)
Show SMILES CCC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N3O3/c1-4-29(35)33-13-12-27(25-17-22(10-11-28(25)33)16-21-8-6-5-7-9-21)32-30(36)26(31)18-24-19(2)14-23(34)15-20(24)3/h5-11,14-15,17,26-27,34H,4,12-13,16,18,31H2,1-3H3,(H,32,36)/t26-,27+/m0/s1
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n/an/an/an/a 32n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50299209
PNG
((5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSCSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C38H42N6O6S2/c39-29(17-24-11-14-28(45)15-12-24)35(47)44-33-21-52-22-51-20-32(34(40)46)43-37(49)31(19-25-10-13-26-8-4-5-9-27(26)16-25)41-36(48)30(42-38(33)50)18-23-6-2-1-3-7-23/h1-16,29-33,45H,17-22,39H2,(H2,40,46)(H,41,48)(H,42,50)(H,43,49)(H,44,47)/t29-,30-,31-,32-,33+/m0/s1
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n/an/an/an/a 36n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat delta opioid receptor expressed in rat C6 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins ...


J Med Chem 52: 7724-31 (2009)


Article DOI: 10.1021/jm9007483
BindingDB Entry DOI: 10.7270/Q2GQ6XTD
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50027089
PNG
(methyl 3-(11-hydroxy-15-methoxy-3-methyl-13-oxa-3-...)
Show SMILES COC(=O)\C=C\C(=O)N[C@H]1C[C@]23C=C[C@]1(OC)[C@@H]1Oc4c5c(CC2N(C)CCC315)ccc4O
Show InChI InChI=1S/C25H28N2O6/c1-27-11-10-24-20-14-4-5-15(28)21(20)33-22(24)25(32-3)9-8-23(24,17(27)12-14)13-16(25)26-18(29)6-7-19(30)31-2/h4-9,16-17,22,28H,10-13H2,1-3H3,(H,26,29)/b7-6+/t16-,17?,22+,23+,24?,25+/m0/s1
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n/an/an/an/a 50n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity was evaluated against [3H]dalamid binding to rat brain membranes (Opioid receptor delta 1)


J Med Chem 27: 1570-4 (1985)


Article DOI: 10.1021/jm00378a008
BindingDB Entry DOI: 10.7270/Q2S18328
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50027089
PNG
(methyl 3-(11-hydroxy-15-methoxy-3-methyl-13-oxa-3-...)
Show SMILES COC(=O)\C=C\C(=O)N[C@H]1C[C@]23C=C[C@]1(OC)[C@@H]1Oc4c5c(CC2N(C)CCC315)ccc4O
Show InChI InChI=1S/C25H28N2O6/c1-27-11-10-24-20-14-4-5-15(28)21(20)33-22(24)25(32-3)9-8-23(24,17(27)12-14)13-16(25)26-18(29)6-7-19(30)31-2/h4-9,16-17,22,28H,10-13H2,1-3H3,(H,26,29)/b7-6+/t16-,17?,22+,23+,24?,25+/m0/s1
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n/an/an/an/a 50n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity was evaluated against [3H]dalamid binding to rat brain membranes (Opioid receptor delta 1)


J Med Chem 27: 1570-4 (1985)


Article DOI: 10.1021/jm00378a008
BindingDB Entry DOI: 10.7270/Q2S18328
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50027090
PNG
(1N-(11-hydroxy-15-methoxy-3-methyl-13-oxa-3-azahex...)
Show SMILES CO[C@]12C=C[C@@]3(C[C@@H]1NC(=O)CBr)C1Cc4ccc(O)c5O[C@@H]2C3(CCN1C)c45
Show InChI InChI=1S/C22H25BrN2O4/c1-25-8-7-21-17-12-3-4-13(26)18(17)29-19(21)22(28-2)6-5-20(21,15(25)9-12)10-14(22)24-16(27)11-23/h3-6,14-15,19,26H,7-11H2,1-2H3,(H,24,27)/t14-,15?,19+,20+,21?,22+/m0/s1
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n/an/an/an/a 50n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity was evaluated against [3H]dalamid binding to neuroblastoma X glioma hybrid cell NG108-15 (Opioid receptor delta 1)membranes


J Med Chem 27: 1570-4 (1985)


Article DOI: 10.1021/jm00378a008
BindingDB Entry DOI: 10.7270/Q2S18328
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50027091
PNG
(19-isothiocyanato-15-methoxy-3-methyl-13-oxa-3-aza...)
Show SMILES CO[C@]12C=C[C@@]3(C[C@@H]1N=C=S)C1Cc4ccc(O)c5O[C@@H]2C3(CCN1C)c45
Show InChI InChI=1S/C21H22N2O3S/c1-23-8-7-20-16-12-3-4-13(24)17(16)26-18(20)21(25-2)6-5-19(20,15(23)9-12)10-14(21)22-11-27/h3-6,14-15,18,24H,7-10H2,1-2H3/t14-,15?,18+,19+,20?,21+/m0/s1
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n/an/an/an/a 50n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity was evaluated against [3H]dalamid binding to rat brain membranes (Opioid receptor delta 1)


J Med Chem 27: 1570-4 (1985)


Article DOI: 10.1021/jm00378a008
BindingDB Entry DOI: 10.7270/Q2S18328
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50225940
PNG
(CHEMBL2310917)
Show SMILES OC(=O)C(O)=O.COC12C=C[C@@]3(C[C@@H]1N)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC=C)c45
Show InChI InChI=1S/C22H26N2O3.C2H2O4/c1-3-9-24-10-8-21-17-13-4-5-14(25)18(17)27-19(21)22(26-2)7-6-20(21,12-15(22)23)16(24)11-13;3-1(4)2(5)6/h3-7,15-16,19,25H,1,8-12,23H2,2H3;(H,3,4)(H,5,6)/t15-,16+,19+,20+,21-,22?;/m0./s1
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n/an/an/an/a 50n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50185314
PNG
(CHEMBL3822963)
Show SMILES COCC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N3O4/c1-19-13-23(34)14-20(2)24(19)17-26(31)30(36)32-27-11-12-33(29(35)18-37-3)28-10-9-22(16-25(27)28)15-21-7-5-4-6-8-21/h4-10,13-14,16,26-27,34H,11-12,15,17-18,31H2,1-3H3,(H,32,36)/t26-,27+/m0/s1
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n/an/an/an/a 67n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR transfected in rat C6 cell membranes after 1 hr by [35S]GTPgammaS assay


J Med Chem 59: 4985-98 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00308
BindingDB Entry DOI: 10.7270/Q28917SS
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50133888
PNG
(CHEMBL3634247)
Show SMILES CC(=O)N1CC[C@@H](NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)c2cc(Cc3ccccc3)ccc12
Show InChI InChI=1S/C29H33N3O3/c1-18-13-23(34)14-19(2)24(18)17-26(30)29(35)31-27-11-12-32(20(3)33)28-10-9-22(16-25(27)28)15-21-7-5-4-6-8-21/h4-10,13-14,16,26-27,34H,11-12,15,17,30H2,1-3H3,(H,31,35)/t26-,27+/m0/s1
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n/an/an/an/a 68n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat delta-opioid receptor expressed in C6 cell membrane assessed as [35S]GTPgammaS binding for 1 hr by liquid scintillation count...


J Med Chem 58: 8952-69 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01270
BindingDB Entry DOI: 10.7270/Q2RR213J
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50427557
PNG
(CHEMBL2322561)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCNc2ccc(Cc3cccc4ccccc34)cc12
Show InChI InChI=1S/C31H33N3O2/c1-19-14-24(35)15-20(2)26(19)18-28(32)31(36)34-30-12-13-33-29-11-10-21(17-27(29)30)16-23-8-5-7-22-6-3-4-9-25(22)23/h3-11,14-15,17,28,30,33,35H,12-13,16,18,32H2,1-2H3,(H,34,36)/t28-,30+/m0/s1
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n/an/an/an/a 69n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat delta-opioid receptor expressed in C6 cell membrane assessed as [35S]GTPgammaS binding for 1 hr by liquid scintillation count...


J Med Chem 58: 8952-69 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01270
BindingDB Entry DOI: 10.7270/Q2RR213J
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50427557
PNG
(CHEMBL2322561)
Show SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H]1CCNc2ccc(Cc3cccc4ccccc34)cc12
Show InChI InChI=1S/C31H33N3O2/c1-19-14-24(35)15-20(2)26(19)18-28(32)31(36)34-30-12-13-33-29-11-10-21(17-27(29)30)16-23-8-5-7-22-6-3-4-9-25(22)23/h3-11,14-15,17,28,30,33,35H,12-13,16,18,32H2,1-2H3,(H,34,36)/t28-,30+/m0/s1
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n/an/an/an/a 69n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR expressed in rat C6 cells assessed as stimulation of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting a...


J Med Chem 56: 2139-49 (2013)


Article DOI: 10.1021/jm400050y
BindingDB Entry DOI: 10.7270/Q2K075MP
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50027090
PNG
(1N-(11-hydroxy-15-methoxy-3-methyl-13-oxa-3-azahex...)
Show SMILES CO[C@]12C=C[C@@]3(C[C@@H]1NC(=O)CBr)C1Cc4ccc(O)c5O[C@@H]2C3(CCN1C)c45
Show InChI InChI=1S/C22H25BrN2O4/c1-25-8-7-21-17-12-3-4-13(26)18(17)29-19(21)22(28-2)6-5-20(21,15(25)9-12)10-14(22)24-16(27)11-23/h3-6,14-15,19,26H,7-11H2,1-2H3,(H,24,27)/t14-,15?,19+,20+,21?,22+/m0/s1
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n/an/an/an/a 70n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity was evaluated against [3H]dalamid binding to rat brain membranes (Opioid receptor delta 1)


J Med Chem 27: 1570-4 (1985)


Article DOI: 10.1021/jm00378a008
BindingDB Entry DOI: 10.7270/Q2S18328
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50225942
PNG
(CHEMBL2310916)
Show SMILES OC(=O)C(O)=O.COC(=O)\C=C\C(=O)N[C@H]1C[C@]23C=CC1(OC)[C@@H]1Oc4c5c(C[C@H]2N(CC=C)CC[C@@]315)ccc4O
Show InChI InChI=1S/C27H30N2O6.C2H2O4/c1-4-12-29-13-11-26-22-16-5-6-17(30)23(22)35-24(26)27(34-3)10-9-25(26,19(29)14-16)15-18(27)28-20(31)7-8-21(32)33-2;3-1(4)2(5)6/h4-10,18-19,24,30H,1,11-15H2,2-3H3,(H,28,31);(H,3,4)(H,5,6)/b8-7+;/t18-,19+,24+,25+,26-,27?;/m0./s1
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n/an/an/an/a 90n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat)-RAT)
BDBM50225932
PNG
(CHEMBL2310918)
Show SMILES OC(=O)C(O)=O.COC12C=C[C@@]3(C[C@@H]1NC(=O)CBr)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC=C)c45
Show InChI InChI=1S/C24H27BrN2O4.C2H2O4/c1-3-9-27-10-8-23-19-14-4-5-15(28)20(19)31-21(23)24(30-2)7-6-22(23,17(27)11-14)12-16(24)26-18(29)13-25;3-1(4)2(5)6/h3-7,16-17,21,28H,1,8-13H2,2H3,(H,26,29);(H,3,4)(H,5,6)/t16-,17+,21+,22+,23-,24?;/m0./s1
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n/an/an/an/a 90n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane


J Med Chem 29: 2136-41 (1986)


Article DOI: 10.1021/jm00161a002
More data for this
Ligand-Target Pair
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