Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50017507
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of N-terminal His6-tagged SARS-CoV2 Wuhan-Hu-1 main protease expressed in Escherichia coli using Dabcyl-KTSAVLQSGFRKME-Edans as substrate ...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM476960(peptidomimetic coronavirus 3CLpro inhibitors 2i)
Affinity DataKi:  15nMAssay Description:Inhibition of SARS-CoV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602412(CHEMBL5184473)
Affinity DataKi:  180nMAssay Description:Inhibition of SARS-CoV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602411(CHEMBL5206685)
Affinity DataKi:  7.10E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro expressed in Escherichia coli BL21(DE3) using Dabcyl-KLSAVLQSGERKM-Edans as substrate assessed as inhibition constant m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602411(CHEMBL5206685)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using CBZ-RLRGG-AMC as substrate assessed as inhibition constant measured for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:Inhibition of SARS-CoV2 main proteaseMore data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602414(CHEMBL5197203)
Affinity DataIC50:  94nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602411(CHEMBL5206685)
Affinity DataIC50:  120nMAssay Description:Inhibition of SARS-CoV-2 MPro expressed in Escherichia coli BL21(DE3) using Dabcyl-KLSAVLQSGERKM-Edans as substrate incubated for 30 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50197349(CHEMBL3983492 | ebselen derivative 1e)
Affinity DataIC50:  256nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598131(CHEMBL599894 | GNF-Pf-3800)
Affinity DataIC50:  260nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602413(CHEMBL5188743)
Affinity DataIC50:  390nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataIC50:  670nMAssay Description:Inhibition of SARS-CoV2 main proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602411(CHEMBL5206685)
Affinity DataIC50:  990nMAssay Description:Inhibition of SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using CBZ-RLRGG-AMC as substrate incubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602411(CHEMBL5206685)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as substrate incubated for 30 mins followed by substrate addition by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602411(CHEMBL5206685)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of His-tagged recombinant human Cathepsin B expressed in HEK293 cells using Z-Leu-Arg-AMC as substrate incubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed