Affinity DataIC50: 600nMAssay Description:Inhibition of SARS CoV-2 PL protease (1541 to 1855 residues) incubated for 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of His tagged SARS-CoV-2 PLpro using Z-RLRGG-AMC as substrate assessed as substrate cleavage preincubated for 60 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of full-length SARS-CoV-2 papain-like protease (1564 to 1878 residues) expressed in Escherichia coli Rosetta (DE3) using Arg-Leu-Arg-Gly-G...More data for this Ligand-Target Pair
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
Affinity DataIC50: 1.61E+3nMAssay Description:The PLpro primary assay, which measures protease activity with the short peptide substrate Z-RLRGG-AMC (Bachem), was performed in black flat-bottom 3...More data for this Ligand-Target Pair
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of N-terminal 3xFlag-His6-tagged SARS-CoV-2 papain-like protease nsp3 (1564 to 1878 residues) expressed in baculovirus infected Sf9 insect...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of N-terminal His/TEV-tagged SARS-CoV-2 papain-like protease nsp3 (746 to 1060 residues) expressed in Escherichia coli BL21 (DE3) using (Z...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of SARS-CoV-2 papain-like protease nsp3 expressed in Escherichia coli BL21 (DE3) using LKGG-AMC probe as substrate by fluorescence based b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...More data for this Ligand-Target Pair
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using Ub-Rho as substrate incubated for 5 mins by enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.97E+3nMAssay Description:Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using HCC-RLRGG-NH(CH2)4NH-DABCYL probe as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataKd: 1.08E+4nMAssay Description:Binding affinity to CM5 chip immobilized full-length wild-type SARS-CoV-2 papain-like protease (1564 to 1878 residues) expressed in Escherichia coli ...More data for this Ligand-Target Pair
Affinity DataKd: 2.70E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 ug/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
Affinity DataEC50: 2.76E+4nMAssay Description:Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...More data for this Ligand-Target Pair