TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKi: 0.300nM Kd: 0.0100nM Kon: 0.000300M-1s-1 Koff: 3.00E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 0.0600nMAssay Description:Binding affinity to DOT1L (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKi: 0.300nM Kd: 0.100nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 0.25nMAssay Description:Binding affinity to DOT1L (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKi: 13nM Kd: 1.70nM Kon: 0.0200M-1s-1 Koff: 1.20E+7s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 66nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKi: 320nM Kd: 71nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKi: 320nM Kd: 71nM Kon: 0.100M-1s-1 Koff: 1.40E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 73nMAssay Description:Competitive inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assa...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 86nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 130nMAssay Description:Competitive inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assa...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 150nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 150nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKi: 845nM Kd: 167nM Kon: 0.200M-1s-1 Koff: 1.20E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKi: 845nM Kd: 167nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 170nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 200nMAssay Description:Competitive inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assa...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 240nMAssay Description:Competitive inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assa...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 360nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 550nMAssay Description:Competitive inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assa...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 1.21E+3nMAssay Description:Binding affinity to recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 4.78E+3nMAssay Description:Binding affinity to recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 7.08E+3nMAssay Description:Binding affinity to recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 7.40E+3nMAssay Description:Binding affinity to recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 9.30E+3nMAssay Description:Binding affinity to recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 1.73E+4nMAssay Description:Binding affinity to human N-terminal 6His-tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) after 150 secs by SPR-based bindin...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Epizyme
US Patent
Epizyme
US Patent
Affinity DataKd: 5.00E+4nMAssay Description:Binding affinity to biotinylated Avi tagged human DoT1L (2 to 416 residues) by SPR analysisMore data for this Ligand-Target Pair