Found 9 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase, H3 lysine-79 specific' and Ligand = 'BDBM50009672'
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Inhibition of human recombinant DOT1L catalytic domain amino acid (1 to 472) using [3H]-SAM after 30 mins by scintillation counterMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Competitive inhibition of recombinant human DOT1L using adenosine/deazaadenosine as substrate and SAM cofactorMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataKi: 270nMAssay Description:Inhibition of DOT1-like Histone H3 Methyltransferase (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of DOTL1 (unknown origin) using [3H]SAM and HeLa oligo nucleosomes as substrates incubated for 1 hrMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant DOT1L (1 to 420 amino acids) expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataKd: 360nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Baylor College Of Medicine
Curated by ChEMBL
Baylor College Of Medicine
Curated by ChEMBL
Affinity DataKd: 150nMAssay Description:Binding affinity at human recombinant DOT1L catalytic domain amino acid (1 to 472)-nucleosome complex by isothermal titration calorimetric assayMore data for this Ligand-Target Pair