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Found 305 Enz. Inhib. hit(s) with Target = 'Pepsin'
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022521(Boc-Phe-His-Cha-CH2-S-Leu-NHCO(CH2)2C6H5 | CHEMBL3...)
Affinity DataIC50: >1nMpH: 1.9Assay Description:Inhibition of porcine pepsin at pH 1.9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50421761(CHEMBL2311113)
Affinity DataIC50:  60nMpH: 2.0Assay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  10nMpH: 2.0Assay Description:Inhibitory activity was evaluated against pepsin using porcine pepsin (sigma), porcine hemoglobin (sigma) and 0.02 M KCl-HCl buffer (pH 2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50025903(4-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...)
Affinity DataIC50:  1.30E+3nMpH: 2.0Assay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17946((2S,4S,7R)-4-amino-7-(butylcarbamoyl)-5-hydroxy-2,...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50025903(4-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...)
Affinity DataIC50:  1.30E+3nMpH: 2.0Assay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17941((2S,4S,5S)-5-[(2S)-2-[(2S)-2-benzyl-3-[(2-methylpr...)
Affinity DataIC50:  8.20E+3nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17942((2R,4S,5S)-5-amino-N-butyl-4-hydroxy-2,7,7-trimeth...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17943(Renin nonpeptide inhibitor, 3 | methyl (3S)-1-[(5S...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17944(Renin nonpeptide inhibitor, 4 | methyl N-[(3R)-1-[...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17945((2S,4S,5S)-5-amino-N-butyl-4-hydroxy-9-[(2S)-2-[(m...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022516(Boc-Trp-Trp-Sta-Ala-Sta-OMe | CHEMBL3142766)
Affinity DataIC50:  120nMpH: 2.0Assay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17947((2R,4S,5S,7R)-5-amino-N-butyl-4-hydroxy-8-{[2-(3-m...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17948((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-({[2-(3-...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17949((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50: >1.00E+5nMpH: 2.0 T: 2°CAssay Description:In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022508(Boc-Pro-Phe-NMe-His-Leu-OHCH2-Val-Ile-Amp | CHEMBL...)
Affinity DataIC50:  6.80nMpH: 2.0Assay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022511(Boc-Trp-His-Sta-Ala-Sta-OMe | CHEMBL3349392)
Affinity DataIC50:  850nMpH: 2.0Assay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022509(Boc-Phe-Phe-Sta-Ala-Sta-OMe | CHEMBL3349390)
Affinity DataIC50:  14nMpH: 2.0Assay Description:Inhibition of porcine pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-5(Homo sapiens (Human))
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022510(Boc-Phe-His-Leu-CF3-Ile-Amp | CHEMBL154795)
Affinity DataIC50:  4.20nMpH: 3.1Assay Description:Inhibition of human pepsin at pH 2.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-5(Homo sapiens (Human))
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022510(Boc-Phe-His-Leu-CF3-Ile-Amp | CHEMBL154795)
Affinity DataIC50:  6nMpH: 3.1Assay Description:Inhibition of bovine cathepsin D at pH 3.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50227343(CHEMBL3349391)
Affinity DataKi: <1nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0 (time-dependent inhibition, T1/2>30 s)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022520(CHEMBL3349395 | H2N-Abu-Pro-Phe-Abu-Sta-Leu-PheOMe)
Affinity DataKi: <1nMpH: 4.0Assay Description:Inhibition of human renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022512(CHEMBL3349394 | Ibu-His-Pro-Phe-Ala-Sta-Leu-PheNH2)
Affinity DataKi:  4nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022517(CHEMBL3349397 | POA-Leu-Sta-Leu-PheOMe)
Affinity DataKi:  12nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022519(CHEMBL3349393 | Ibu-His-Pro-Phe-His-Sta-Leu-PheNH2)
Affinity DataKi:  23nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022507(CHEMBL3349407 | H2N-His-Pro-Phe-His-Sta-Leu-PheOMe)
Affinity DataKi:  34nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022515(CHEMBL3349396 | POA-His-Sta-Leu-PheOMe)
Affinity DataKi:  67nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022513(CHEMBL3349389 | H2N-Phe-Gly-His-(S,S)-Sta-Ala-Phe-...)
Affinity DataKi:  150nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50022523(CHEMBL347185 | H2N-Phe-Gly-His-Nph-Phe-Ala-Phe-OMe)
Affinity DataKi:  4.00E+4nMpH: 4.0Assay Description:Inhibition of porcine pepsin at pH 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16755(Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50012626(3-hydroxy-4-[2-methyl-1-[2-methyl-1-benzyloxycarbo...)
Affinity DataKi:  0nMAssay Description:Compound was measured for the apparent inhibition constant at pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataKi:  0nMAssay Description:Compound was measured for the inhibition of pepsin hydrolysis of hemoglobin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50012623(3-hydroxy-6-methyl-4-[2-methyl-1-[2-methyl-1-benzy...)
Affinity DataKi:  0nMAssay Description:Compound was measured for the apparent inhibition constant at pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50012624(3-hydroxy-4-[2-methyl-1-[2-methyl-1-benzyloxycarbo...)
Affinity DataKi:  0nMAssay Description:Compound was measured for the apparent inhibition constant at pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50012622(3-hydroxy-4-[2-methyl-1-[2-methyl-1-benzyloxycarbo...)
Affinity DataKi:  0.0180nMAssay Description:Compound was measured for the apparent inhibition constant at pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50012618(3-hydroxy-6-methyl-4-[2-methyl-1-[2-methyl-1-benzy...)
Affinity DataKi:  0.0390nMAssay Description:Compound was measured for the apparent inhibition constant at pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50028313(3-Hydroxy-6-methyl-4-{3-methyl-2-[3-methyl-2-(3-me...)
Affinity DataKi:  0.0457nMAssay Description:Pepsin inhibition was measured using the synthetic heptapeptide substrate Phe-Gly-His-Phe-(N02)-Phe-Ala- Phe-OMeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50141614((1S,2S,5S)-3-Hydroxy-4-[2-((S)-hydroxy-6-(S)-4-{(S...)
Affinity DataKi:  0.0460nMAssay Description:Inhibitory activity of the compound against aspartyl protease pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataKi:  0.0560nMAssay Description:Inhibition of porcine pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPepsin A-5(Homo sapiens (Human))
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50108795(CHEMBL3143435 | {1-[1-(1-{1-Hydroxy-1-methyl-2-[1-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50225475(CHEMBL92625)
Affinity DataKi: <0.100nMAssay Description:Inhibition of porcine pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50025532(3-Hydroxy-6-methyl-4-[3-methyl-2-(2-methyl-butyryl...)
Affinity DataKi:  0.180nMAssay Description:The compound was tested for inhibition of carboxyl protease (pepsin) inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50025525(4-[2-(2-Ethyl-butyrylamino)-3-methyl-butyrylamino]...)
Affinity DataKi:  0.310nMAssay Description:The compound was tested for inhibition of carboxyl protease (pepsin) inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50012621(3-hydroxy-4-[2-methyl-1-[2-methyl-1-benzyloxycarbo...)
Affinity DataKi:  0.346nMAssay Description:Compound was measured for the apparent inhibition constant at pepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50025514(2-{2-[2-(4-{2-[2-(2-tert-Butoxycarbonylamino-3-phe...)
Affinity DataKi:  0.640nMAssay Description:Compound was tested for inhibition of pepsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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