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Found 32 Enz. Inhib. hit(s) with all data for entry = 10168
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  2.10nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  2.60nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM50332929(((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-di...)
Affinity DataIC50:  120nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM50461737(CHEMBL4227977 | US11001595, Compound 7 | US1111125...)
Affinity DataIC50:  160nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  177nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM50461741(CHEMBL4227112 | US11001595, Compound 6 | US1111125...)
Affinity DataIC50:  210nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497332(US11001595, Compound 4 | US11111252, Compound 3)
Affinity DataIC50:  213nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  230nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497336(US11001595, Compound 9 | US11111252, Compound 9)
Affinity DataIC50:  234nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  252nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  260nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  624nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  910nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497332(US11001595, Compound 4 | US11111252, Compound 3)
Affinity DataIC50:  970nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497336(US11001595, Compound 9 | US11111252, Compound 9)
Affinity DataIC50:  1.10E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM50461741(CHEMBL4227112 | US11001595, Compound 6 | US1111125...)
Affinity DataIC50:  1.40E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  1.41E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM50461737(CHEMBL4227977 | US11001595, Compound 7 | US1111125...)
Affinity DataIC50:  1.90E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  2.80E+3nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM50111603(3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-...)
Affinity DataIC50:  3.75E+3nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  3.90E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  6.90E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  1.04E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  1.29E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497346(US11001595, Compound CB67645 | US11111252, Compoun...)
Affinity DataIC50:  1.41E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  1.51E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  2.26E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM50332929(((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-di...)
Affinity DataIC50:  3.22E+4nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  4.03E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  5.63E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497327(US11001595, Compound 1 | US11001595, Compound 5 | ...)
Affinity DataIC50:  1.18E+5nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University Of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  1.60E+5nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent