Compile Data Set for Download or QSAR
maximum 50k data
Found 6 Enz. Inhib. hit(s) with all data for entry = 2609
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22578(2-[(E)-2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfoph...)
Affinity DataKi:  7.10E+3nM ΔG°:  -29.1kJ/mole IC50:  1.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22584(5-bromo-2-[9-chloro-3-(sulfooxy)naphtho[1,2-b]thio...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22580(47729-M | 5-chloro-2-{5-hydroxy-3-methyl-4-[(E)-2-...)
Affinity DataIC50:  3.30E+3nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22582(324572-F | 4-{3-methyl-4-[(E)-2-[3-methyl-4-(pheny...)
Affinity DataIC50:  1.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22583(2,5-dichloro-4-{3-methyl-5-oxo-4-[(E)-2-(4-sulfoph...)
Affinity DataIC50:  2.01E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22581(324571-C | 4-chloro-2-[(E)-2-[5-hydroxy-3-methyl-1...)
Affinity DataIC50:  4.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed