Compile Data Set for Download or QSAR
maximum 50k data
Found 30 Enz. Inhib. hit(s) with all data for entry = 50015624
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119366((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataKi:  1.20nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  1.80nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152799((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [125]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  11nMAssay Description:Displacement of [125]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)
Affinity DataKi:  21nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155380(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)
Affinity DataKi:  44nMAssay Description:Displacement of [125]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155382(4-(2R)-[2-methoxyacetamido]3-(4-chlorophenyl)propi...)
Affinity DataKi:  70nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50134486((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  270nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  280nMAssay Description:Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152806((R)-N-((R)-1-(4-(2-(aminomethyl)phenyl)piperazin-1...)
Affinity DataKi:  380nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  640nMAssay Description:Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  646nMAssay Description:Displacement of [125I]NDP-alpha-MSH from MC4R D122A mutant expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155380(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)
Affinity DataKi:  990nMAssay Description:Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155380(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152806((R)-N-((R)-1-(4-(2-(aminomethyl)phenyl)piperazin-1...)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  4.20E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119367((3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-...)
Affinity DataIC50:  0.300nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119373((2S)-2-amino-3-(1H-imidazol-4-yl)-N-[(2R)-1-{1-met...)
Affinity DataIC50:  108nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119372((R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclo...)
Affinity DataIC50:  238nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50155380(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)
Affinity DataEC50:  580nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  49nMAssay Description:Agonist activity at human MC4 D122A mutant expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152799((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at human MC4 receptor expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152806((R)-N-((R)-1-(4-(2-(aminomethyl)phenyl)piperazin-1...)
Affinity DataEC50:  890nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50134486((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed