BDBM50134486 (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-1-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide::(R)-N-((R)-1-(4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-1-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide::CHEMBL340355
SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2Cn2cncn2)cc1
InChI Key InChIKey=PKHOEKKVDQTOOR-FQLXRVMXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50134486
Affinity DataKi: 24nMAssay Description:Displacement of [125I]-NDP-MSH from HEK293 cells expressing human melanocortin-3 receptor at 10 uMMore data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Binding affinity to human MC4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+3nMAssay Description:In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 5 receptor (hMC5R)More data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Agonistic activity measured as inhibition of cAMP accumulation in HEK cells expressing human Melanocortin 4 receptor (hMC4R)More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences
Curated by ChEMBL
Neurocrine Biosciences
Curated by ChEMBL
Affinity DataEC50: >3.00E+3nMAssay Description:In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro cAMP accumulation in Y1 cells transfected with mouse Melanocortin 2 receptor (mMC2R)More data for this Ligand-Target Pair
Affinity DataEC50: 59nMAssay Description:In vitro cAMP accumulation in Y1 cells transfected with mouse Melanocortin 4 receptor (mMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+3nMAssay Description:In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)More data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair