Compile Data Set for Download or QSAR
maximum 50k data
Found 49 Enz. Inhib. hit(s) with all data for entry = 50037439
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164772((2S,5S)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164760((2S,5S)-5-Ethyl-piperazine-2-carboxylic acid [(R)-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164763((2S,5S)-5-Isopropyl-piperazine-2-carboxylic acid [...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164766((2S,5S)-5-(1-Methyl-cyclopropyl)-piperazine-2-carb...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164775((2S,5S)-5-tert-Butyl-piperazine-2-carboxylic acid ...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164762((2S,5S)-5-Methyl-piperazine-2-carboxylic acid [(R)...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164771((2S,5S)-5-Cyclopropyl-piperazine-2-carboxylic acid...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027169(CHEMBL2028962)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027168(CHEMBL2028961)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027174(CHEMBL2028957)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027172(CHEMBL2028960)
Affinity DataIC50:  24nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027170(CHEMBL2028958)
Affinity DataIC50:  25nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027171(CHEMBL2028959)
Affinity DataIC50:  29nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027173(CHEMBL2028956)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164774((2S,5R)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataIC50:  46nMAssay Description:Inhibitory concentration to displace [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027168(CHEMBL2028961)
Affinity DataEC50:  41nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027169(CHEMBL2028962)
Affinity DataEC50:  18nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027171(CHEMBL2028959)
Affinity DataEC50:  1.00E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027170(CHEMBL2028958)
Affinity DataEC50:  1.40E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164760((2S,5S)-5-Ethyl-piperazine-2-carboxylic acid [(R)-...)
Affinity DataEC50:  5nMAssay Description:Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164762((2S,5S)-5-Methyl-piperazine-2-carboxylic acid [(R)...)
Affinity DataEC50:  880nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164763((2S,5S)-5-Isopropyl-piperazine-2-carboxylic acid [...)
Affinity DataEC50:  3nMAssay Description:Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164772((2S,5S)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataEC50:  450nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164762((2S,5S)-5-Methyl-piperazine-2-carboxylic acid [(R)...)
Affinity DataEC50:  8nMAssay Description:Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164763((2S,5S)-5-Isopropyl-piperazine-2-carboxylic acid [...)
Affinity DataEC50:  340nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164766((2S,5S)-5-(1-Methyl-cyclopropyl)-piperazine-2-carb...)
Affinity DataEC50:  300nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164760((2S,5S)-5-Ethyl-piperazine-2-carboxylic acid [(R)-...)
Affinity DataEC50:  710nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164775((2S,5S)-5-tert-Butyl-piperazine-2-carboxylic acid ...)
Affinity DataEC50:  360nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164772((2S,5S)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataEC50:  2nMAssay Description:Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164774((2S,5R)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataEC50:  2.40E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164771((2S,5S)-5-Cyclopropyl-piperazine-2-carboxylic acid...)
Affinity DataEC50:  760nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164771((2S,5S)-5-Cyclopropyl-piperazine-2-carboxylic acid...)
Affinity DataEC50:  5nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027172(CHEMBL2028960)
Affinity DataEC50:  93nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027171(CHEMBL2028959)
Affinity DataEC50:  91nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164766((2S,5S)-5-(1-Methyl-cyclopropyl)-piperazine-2-carb...)
Affinity DataEC50:  7nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027172(CHEMBL2028960)
Affinity DataEC50:  920nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027170(CHEMBL2028958)
Affinity DataEC50:  36nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataEC50:  1.90nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027168(CHEMBL2028961)
Affinity DataEC50:  1.90E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164774((2S,5R)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataEC50:  330nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164775((2S,5S)-5-tert-Butyl-piperazine-2-carboxylic acid ...)
Affinity DataEC50:  7nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027174(CHEMBL2028957)
Affinity DataEC50:  1.40E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027174(CHEMBL2028957)
Affinity DataEC50:  42nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataEC50:  1.10nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027173(CHEMBL2028956)
Affinity DataEC50:  150nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataEC50:  17nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164772((2S,5S)-5-Ethyl-4-methyl-piperazine-2-carboxylic a...)
Affinity DataEC50:  150nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027173(CHEMBL2028956)
Affinity DataEC50:  45nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed