Compile Data Set for Download or QSAR
maximum 50k data
Found 56 Enz. Inhib. hit(s) with all data for entry = 50032024
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323446(2-((S)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophe...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323456((S)-(6-chloro-5-methyl-3-(2-morpholinopropan-2-yl)...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323458((S)-(6-chloro-3-(2-((S)-3-hydroxypyrrolidin-1-yl)p...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323457((S)-(6-chloro-5-methyl-3-(2-(pyrrolidin-1-yl)propa...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323455((S)-(6-chloro-3-(2-(ethylamino)propan-2-yl)-5-meth...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323453((S)-(6-chloro-3-(2-(dimethylamino)propan-2-yl)-5-m...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323459((S)-(6-chloro-3-(2-(3,3-difluoropyrrolidin-1-yl)pr...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323440(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  2.80nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323454((S)-(6-chloro-5-methyl-3-(2-(methylamino)propan-2-...)
Affinity DataIC50:  3.60nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323451(CHEMBL1209794 | N-(2-((S)-6-chloro-1'-((3S,4R)-4-(...)
Affinity DataIC50:  6.20nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323443(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  6.60nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323450(2-((S)-5-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  7.30nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323449(2-((S)-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetra...)
Affinity DataIC50:  7.60nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323444(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323439(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323447(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophe...)
Affinity DataIC50:  31nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323445(2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl...)
Affinity DataIC50:  44nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323442(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  53nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  123nMAssay Description:Inhibition of human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323452(CHEMBL1209795 | N-(2-((R)-6-chloro-1'-((3S,4R)-4-(...)
Affinity DataIC50:  151nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323448((3S,4R)-tert-butyl 3-((S)-6-chloro-3-(2-cyanopropa...)
Affinity DataIC50:  479nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  483nMAssay Description:Inhibition of human melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323445(2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl...)
Affinity DataEC50:  615nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at rat melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323446(2-((S)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophe...)
Affinity DataEC50:  115nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323448((3S,4R)-tert-butyl 3-((S)-6-chloro-3-(2-cyanopropa...)
Affinity DataEC50:  1.01E+3nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323439(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  78nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323442(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  96nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323443(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323444(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  465nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323443(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  295nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323442(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  735nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323440(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  343nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323439(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323456((S)-(6-chloro-5-methyl-3-(2-morpholinopropan-2-yl)...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323455((S)-(6-chloro-3-(2-(ethylamino)propan-2-yl)-5-meth...)
Affinity DataEC50:  3.30nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323458((S)-(6-chloro-3-(2-((S)-3-hydroxypyrrolidin-1-yl)p...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323457((S)-(6-chloro-5-methyl-3-(2-(pyrrolidin-1-yl)propa...)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323452(CHEMBL1209795 | N-(2-((R)-6-chloro-1'-((3S,4R)-4-(...)
Affinity DataEC50:  352nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323451(CHEMBL1209794 | N-(2-((S)-6-chloro-1'-((3S,4R)-4-(...)
Affinity DataEC50:  7.40nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323454((S)-(6-chloro-5-methyl-3-(2-(methylamino)propan-2-...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323453((S)-(6-chloro-3-(2-(dimethylamino)propan-2-yl)-5-m...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323450(2-((S)-5-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323459((S)-(6-chloro-3-(2-(3,3-difluoropyrrolidin-1-yl)pr...)
Affinity DataEC50:  2.90nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at mouse melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  767nMAssay Description:Agonist activity at human melanocortin 3 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323440(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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