BDBM50323442 2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile::CHEMBL1209789

SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(CC4CCOCC4)C[C@H]3c3ccc(F)cc3F)c2cc1Cl)C(C)(C)C#N

InChI Key InChIKey=JXKLEENGOVSQKK-PZXMZKPCSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50323442   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323442(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataIC50:  53nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323442(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  96nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323442(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  735nMAssay Description:Inhibition of human melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed