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Found 21 Enz. Inhib. hit(s) with all data for entry = 50028925
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity of the compound against human platelet 12-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  420nMAssay Description:Inhibitory activity of the compound against soyabean 15-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  520nMAssay Description:Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  520nMAssay Description:Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1/2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against intact rat PMNL, PGE-2 cyclooxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009941(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009941(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50009941(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50009941(1-Phenyl-tetrahydro-pyridazin-3-one | CHEMBL30110)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibitory activity of the compound against RBL broken cell-supematant 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory activity of the compound against intact rat PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory activity against human whole blood, TXB2 cyclooxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1/2(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory activity of the compound against human whole blood, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibitory activity of the compound against intact human PMNL, LTB4 5-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  9.70E+4nMAssay Description:Association rate constant of the compound was determined against 3-dehydroquinate synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000540(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  2.13E+5nMAssay Description:Inhibitory activity of the compound against soyabean 15-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article